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pak-2 Serine/threonine-protein kinase pak-2 [ Caenorhabditis elegans ]

Gene ID: 179527, updated on 2-Nov-2024

Summary

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Official Symbol
pak-2
Official Full Name
Serine/threonine-protein kinase pak-2
Primary source
WormBase:WBGene00006443
Locus tag
CELE_C45B11.1
See related
AllianceGenome:WB:WBGene00006443
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable protein serine/threonine kinase activity. Involved in nematode larval development. Predicted to be active in cytoplasm. Is expressed in hypodermis; nervous system; pharyngeal-intestinal valve; and pharynx. Human ortholog(s) of this gene implicated in clear cell renal cell carcinoma. Orthologous to several human genes including PAK4 (p21 (RAC1) activated kinase 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pak-2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
6
Sequence:
Chromosome: V; NC_003283.11 (11036461..11039429, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Ac108 Neighboring gene Transmembrane protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A protein related to p21-activated kinase (PAK) that is involved in neurogenesis in the Drosophila adult central nervous system. Melzig J, et al. Curr Biol, 1998 Nov 5. PMID 9811608
  2. Genes implicated in Caenorhabditis elegans and human health regulate stress resistance and physical abilities in aged Caenorhabditis elegans. Dysarz J, et al. Biol Lett, 2021 Jun. PMID 34102068, Free PMC Article
  3. The Caenorhabditis elegans Ste20-related kinase and Rac-type small GTPase regulate the c-Jun N-terminal kinase signaling pathway mediating the stress response. Fujiki K, et al. Mol Cell Biol, 2010 Feb. PMID 20008556, Free PMC Article
  4. The Caenorhabditis elegans P21-activated kinases are differentially required for UNC-6/netrin-mediated commissural motor axon guidance. Lucanic M, et al. Development, 2006 Nov. PMID 17050621
  5. Healthspan pathway maps in C. elegans and humans highlight transcription, proliferation/biosynthesis and lipids. Möller S, et al. Aging (Albany NY), 2020 Jul 7. PMID 32634117, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cellular response to starvation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in nematode larval development IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
involved_in regulation of MAPK cascade IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Serine/threonine-protein kinase pak-2
NP_505809.2
  • Confirmed by transcript evidence
NP_505810.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    11036461..11039429 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073409.7 → NP_505810.2  Serine/threonine-protein kinase pak-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505810.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EFU0
    Conserved Domains (3) summary
    smart00220
    Location:230 → 480
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01093
    Location:14 → 60
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    cl21453
    Location:221 → 481
    PKc_like; Protein Kinases, catalytic domain

  2. NM_073408.6 → NP_505809.2  Serine/threonine-protein kinase pak-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505809.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EFU0, Q9U3M1
    Conserved Domains (3) summary
    smart00220
    Location:232 → 482
    S_TKc; Serine/Threonine protein kinases, catalytic domain
    cd01093
    Location:14 → 60
    CRIB_PAK_like; PAK (p21 activated kinase) Binding Domain (PBD), binds Cdc42p- and/or Rho-like small GTPases; also known as the Cdc42/Rac interactive binding (CRIB) motif; has been shown to inhibit transcriptional activation and cell transformation mediated by the ...
    cl21453
    Location:223 → 483
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
G5EFU0.1

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