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Y42A5A.1 Aminopeptidase [ Caenorhabditis elegans ]

Gene ID: 179536, updated on 2-Nov-2024

Summary

Official Symbol
Y42A5A.1
Official Full Name
Aminopeptidase
Primary source
WormBase:WBGene00012776
Locus tag
CELE_Y42A5A.1
See related
AllianceGenome:WB:WBGene00012776
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable metalloaminopeptidase activity; peptide binding activity; and zinc ion binding activity. Predicted to be involved in peptide catabolic process and proteolysis. Predicted to be active in cytoplasm; extracellular space; and membrane. Orthologous to human TRHDE (thyrotropin releasing hormone degrading enzyme). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

See Y42A5A.1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
19
Sequence:
Chromosome: V; NC_003283.11 (11087948..11097985)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Beta-lactamase-related domain-containing protein Neighboring gene ncRNA Neighboring gene FMRF-Like Peptide Neighboring gene ncRNA Neighboring gene Cyclin-dependent kinase-like 1;Protein kinase domain-containing protein Neighboring gene LYR motif-containing protein 5 Neighboring gene pseudo

General gene information

Markers

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
 
enables metalloaminopeptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
 
enables metallopeptidase activity IEA
Inferred from Electronic Annotation
more info
 
enables peptide binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion binding IBA
Inferred from Biological aspect of Ancestor
more info
 
enables zinc ion binding IEA
Inferred from Electronic Annotation
more info
 
Process Evidence Code Pubs
involved_in peptide catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
 
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
 
is_active_in membrane IBA
Inferred from Biological aspect of Ancestor
more info
 
located_in membrane IEA
Inferred from Electronic Annotation
more info
 

General protein information

Preferred Names
Aminopeptidase
NP_505820.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    11087948..11097985
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073419.6NP_505820.1  Aminopeptidase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505820.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9U2H2
    Conserved Domains (3) summary
    cd09601
    Location:181623
    M1_APN_2; Peptidase M1 Aminopeptidase N family incudes tricorn interacting factor F3, Endoplasmic reticulum aminopeptidase 1 (ERAP1), Aminopeptidase Q (APQ)
    pfam01433
    Location:159549
    Peptidase_M1; Peptidase family M1
    pfam11838
    Location:688998
    ERAP1_C; ERAP1-like C-terminal domain