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mboa-2 O-acyltransferase;diacylglycerol O-acyltransferase [ Caenorhabditis elegans ]

Gene ID: 179540, updated on 2-Nov-2024

Summary

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Official Symbol
mboa-2
Official Full Name
O-acyltransferase;diacylglycerol O-acyltransferase
Primary source
WormBase:WBGene00010408
Locus tag
CELE_H19N07.4
See related
AllianceGenome:WB:WBGene00010408
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable diacylglycerol O-acyltransferase activity. Predicted to be involved in triglyceride biosynthetic process. Predicted to be located in endoplasmic reticulum and membrane. Predicted to be active in endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in cardiomyopathy and congenital diarrhea 7 with exudative enteropathy. Orthologous to human DGAT1 (diacylglycerol O-acyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mboa-2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
7
Sequence:
Chromosome: V; NC_003283.11 (11119813..11122493, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Eukaryotic peptide chain release factor GTP-binding subunit;Translation elongation factor EFTu/EF1A C-terminal domain-containing protein Neighboring gene Ubiquitin carboxyl-terminal hydrolase 7 Neighboring gene MRG domain-containing protein Neighboring gene ATP synthase subunit d, mitochondrial Neighboring gene Late endosomal/lysosomal adaptor and MAPK and MTOR activator 5

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Neuronal lipolysis participates in PUFA-mediated neural function and neurodegeneration. Yang L, et al. EMBO Rep, 2020 Nov 5. PMID 33034119, Free PMC Article
  2. CEST-2.2 overexpression alters lipid metabolism and extends longevity of mitochondrial mutants. Piazzesi A, et al. EMBO Rep, 2022 May 4. PMID 35297148, Free PMC Article
  3. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables diacylglycerol O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables diacylglycerol O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables retinol O-fatty-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in glycerolipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in retinol metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in triglyceride biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in triglyceride biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
O-acyltransferase;diacylglycerol O-acyltransferase
NP_001256301.2
  • Confirmed by transcript evidence
NP_001256302.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    11119813..11122493 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001269372.3 → NP_001256301.2  O-acyltransferase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EBH6, Q9NCE1
    Conserved Domains (1) summary
    cl00738
    Location:67 → 477
    MBOAT; MBOAT, membrane-bound O-acyltransferase family

  2. NM_001269373.3 → NP_001256302.1  diacylglycerol O-acyltransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256302.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F1LIN4
    Conserved Domains (1) summary
    cl00738
    Location:1 → 295
    MBOAT; MBOAT, membrane-bound O-acyltransferase family
Nucleotide Protein
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