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folt-1 Folate transporter 1 [ Caenorhabditis elegans ]

Gene ID: 179544, updated on 2-Nov-2024

Summary

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Official Symbol
folt-1
Official Full Name
Folate transporter 1
Primary source
WormBase:WBGene00007388
Locus tag
CELE_C06H2.4
See related
AllianceGenome:WB:WBGene00007388
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable folic acid binding activity and vitamin transmembrane transporter activity. Predicted to be involved in transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Is expressed in several structures, including body wall musculature; intestine; pharynx; reproductive system; and tail. Human ortholog(s) of this gene implicated in several diseases, including abdominal aortic aneurysm; biotin-responsive basal ganglia disease; cleft lip; dextro-looped transposition of the great arteries; and megaloblastic anemia. Orthologous to several human genes including SLC19A3 (solute carrier family 19 member 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See folt-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
5
Sequence:
Chromosome: V; NC_003283.11 (11141479..11143121)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene GLOBIN domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene F-box domain-containing protein Neighboring gene Uncharacterized protein Neighboring gene Neuropeptide-like protein 33

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Knockout of the folate transporter folt-1 causes germline and somatic defects in C. elegans. Austin MU, et al. BMC Dev Biol, 2010 May 4. PMID 20441590, Free PMC Article
  2. Cloning and functional characterization of a folate transporter from the nematode Caenorhabditis elegans. Balamurugan K, et al. Am J Physiol Cell Physiol, 2007 Aug. PMID 17475669
  3. Folate receptor overexpression induces toxicity in a diet-dependent manner in C. elegans. Shrestha B, et al. Sci Rep, 2024 Jan 11. PMID 38212621, Free PMC Article
  4. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  5. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables folic acid binding IEA
Inferred from Electronic Annotation
more info
  
enables vitamin transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in vitamin transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in vitamin transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Folate transporter 1
NP_505833.3
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    11141479..11143121
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073432.5 → NP_505833.3  Folate transporter 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505833.3

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    A3FMP6, Q17766
    Conserved Domains (1) summary
    pfam01770
    Location:2 → 403
    Folate_carrier; Reduced folate carrier
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q17766.3

Gene LinkOut

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