grl-7 Ground-like domain-containing protein [Caenorhabditis elegans] - Gene

Summary

Go to the top of the page Help

Official Symbol: grl-7
Official Full Name: Ground-like domain-containing protein
Primary source: WormBase:WBGene00001716
Locus tag: CELE_T02E9.2
See related: AllianceGenome:WB:WBGene00001716
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Located in apical plasma membrane. Is expressed in hypodermis; intestine; and ventral cord blast cell. [provided by Alliance of Genome Resources, Nov 2024]
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See grl-7 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 6

Sequence:: Chromosome: V; NC_003283.11 (11344828..11347012, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Caenorhabditis elegans PTR/PTCHD PTR-18 promotes the clearance of extracellular hedgehog-related protein via endocytosis.
Title: Caenorhabditis elegans PTR/PTCHD PTR-18 promotes the clearance of extracellular hedgehog-related protein via endocytosis.
Provide evidence that two hedgehog-related (hh-r) genes, grl-5 and grl-7, are targets of miR-235 that promote reactivation of quiescent neuroblasts. These grl genes possess an miR-235 binding site on 3'UTRs of their transcripts, and are upregulated in starved mir-235 mutant larvae.
Title: Hedgehog-related genes regulate reactivation of quiescent neural progenitors in Caenorhabditis elegans.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Markers

T02E9.2 (e-PCR)
- UniSTS:305880

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Component	Evidence Code	Pubs
located_in apical plasma membrane	IDA Inferred from Direct Assay more info	PubMed

General protein information

Go to the top of the page Help

Preferred Names: Ground-like domain-containing protein

NP_001024093.1

Confirmed by transcript evidence

NP_001024094.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

11344828..11347012 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001028923.7 → NP_001024094.1 Ground-like domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024094.1

Status: REVIEWED

UniProtKB/TrEMBL

Q52GX6

Conserved Domains (2) summary

PRK07764
Location:45 → 163

PRK07764; DNA polymerase III subunits gamma and tau; Validated

pfam04155
Location:260 → 330

Ground-like; Ground-like domain
NM_001028922.4 → NP_001024093.1 Ground-like domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024093.1

Status: REVIEWED

UniProtKB/TrEMBL

O18015

Conserved Domains (2) summary

PRK07764
Location:45 → 160

PRK07764; DNA polymerase III subunits gamma and tau; Validated

pfam04155
Location:279 → 349

Ground-like; Ground-like domain