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skp-1 mammalian SKIP (Ski interacting protein) homolog [ Caenorhabditis elegans ]

Gene ID: 179598, updated on 2-Nov-2024

Summary

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Official Symbol
skp-1
Official Full Name
mammalian SKIP (Ski interacting protein) homolog
Primary source
WormBase:WBGene00004806
Locus tag
CELE_T27F2.1
See related
AllianceGenome:WB:WBGene00004806
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in several processes, including egg-laying behavior; uterus development; and vulval development. Predicted to be part of spliceosomal complex. Is expressed in egg-laying apparatus; hypodermis; pharynx; rectal muscle; and somatic nervous system. Human ortholog(s) of this gene implicated in breast cancer and pancreatic cancer. Orthologous to human SNW1 (SNW domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See skp-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
6
Sequence:
Chromosome: V; NC_003283.11 (11645481..11650090)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Chromosomal passenger complex protein bir-1 Neighboring gene Transcription factor zip-10 Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. SKIP is an indispensable factor for Caenorhabditis elegans development. Kostrouchova M, et al. Proc Natl Acad Sci U S A, 2002 Jul 9. PMID 12084813, Free PMC Article
  2. BIR-1, a Caenorhabditis elegans homologue of Survivin, regulates transcription and development. Kostrouchova M, et al. Proc Natl Acad Sci U S A, 2003 Apr 29. PMID 12682297, Free PMC Article
  3. SKIP, a CBF1-associated protein, interacts with the ankyrin repeat domain of NotchIC To facilitate NotchIC function. Zhou S, et al. Mol Cell Biol, 2000 Apr. PMID 10713164, Free PMC Article
  4. Functional recovery of the germ line following splicing collapse. Cao W, et al. Cell Death Differ, 2022 Apr. PMID 34663906, Free PMC Article
  5. BIR-1, the homologue of human Survivin, regulates expression of developmentally active collagen genes in C. elegans. Libý P, et al. Folia Biol (Praha), 2006. PMID 17116281

See all (25) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Skp1 proteins are structural components of the synaptonemal complex in C. elegans.
    Title: Skp1 proteins are structural components of the synaptonemal complex in C. elegans.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in embryo development ending in birth or egg hatching IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in germ cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in locomotion IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
involved_in molting cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nematode larval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of DNA-templated transcription ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
involved_in regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in uterus development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in vulval development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
mammalian SKIP (Ski interacting protein) homolog
NP_505950.1
  • Product from WormBase gene class skp;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    11645481..11650090
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073549.10 → NP_505950.1  mammalian SKIP (Ski interacting protein) homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505950.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22836
    Conserved Domains (1) summary
    pfam02731
    Location:183 → 323
    SKIP_SNW; SKIP/SNW domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q22836.1

Gene LinkOut

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