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pyc-1 Pyruvate carboxylase 1;Pyruvate carboxylase subunit B [ Caenorhabditis elegans ]

Gene ID: 179616, updated on 2-Nov-2024

Summary

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Official Symbol
pyc-1
Official Full Name
Pyruvate carboxylase 1;Pyruvate carboxylase subunit B
Primary source
WormBase:WBGene00004258
Locus tag
CELE_D2023.2
See related
AllianceGenome:WB:WBGene00004258
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable pyruvate carboxylase activity. Predicted to be involved in gluconeogenesis and pyruvate metabolic process. Located in mitochondrion. Used to study pyruvate decarboxylase deficiency. Human ortholog(s) of this gene implicated in pyruvate carboxylase deficiency disease. Orthologous to human PC (pyruvate carboxylase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pyc-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
9
Sequence:
Chromosome: V; NC_003283.11 (11817783..11822365, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene C2 domain-containing protein Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Thialysine N-epsilon-acetyltransferase Neighboring gene Putative thiosulfate sulfurtransferase mpst-1

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of a cadmium-inducible isoform of pyruvate carboxylase from Caenorhabditis elegans. Liao VH, et al. DNA Seq, 2001. PMID 11761713
  2. Mitochondrial SIRT4-type proteins in Caenorhabditis elegans and mammals interact with pyruvate carboxylase and other acetylated biotin-dependent carboxylases. Wirth M, et al. Mitochondrion, 2013 Nov. PMID 23438705, Free PMC Article
  3. Global analysis of dauer gene expression in Caenorhabditis elegans. Wang J, et al. Development, 2003 Apr. PMID 12620986
  4. The NAD(+)/Sirtuin Pathway Modulates Longevity through Activation of Mitochondrial UPR and FOXO Signaling. Mouchiroud L, et al. Cell, 2013 Jul 18. PMID 23870130, Free PMC Article
  5. Mass spectrometric proteome analysis for profiling temperature-dependent changes of protein expression in wild-type Caenorhabditis elegans. Mádi A, et al. Proteomics, 2003 Aug. PMID 12923778

See all (27) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables catalytic activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables pyruvate carboxylase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyruvate carboxylase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in gluconeogenesis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in gluconeogenesis IEA
Inferred from Electronic Annotation
more info
  
involved_in pyruvate metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyruvate metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrion HDA PubMed 

General protein information

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Preferred Names
Pyruvate carboxylase 1;Pyruvate carboxylase subunit B
NP_001368099.1
  • Confirmed by transcript evidence
NP_001369995.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    11817783..11822365 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001383412.2 → NP_001369995.1  Pyruvate carboxylase 1 [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O17732
    Conserved Domains (1) summary
    PRK12999
    Location:28 → 1175
    PRK12999; pyruvate carboxylase; Reviewed

  2. NM_001380776.1 → NP_001368099.1  Pyruvate carboxylase subunit B [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2L2E4
    Conserved Domains (1) summary
    cl39082
    Location:2 → 616
    PycA; Pyruvate carboxylase [Energy production and conversion]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O17732.1

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