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pho-8 intestinal acid PHOsphatase [ Caenorhabditis elegans ]

Gene ID: 179621, updated on 2-Nov-2024

Summary

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Official Symbol
pho-8
Official Full Name
intestinal acid PHOsphatase
Primary source
WormBase:WBGene00011262
Locus tag
CELE_R13H4.3
See related
AllianceGenome:WB:WBGene00011262
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable phosphatase activity. Human ortholog(s) of this gene implicated in amelogenesis imperfecta type 1J. Orthologous to human ACP2 (acid phosphatase 2, lysosomal) and ACP4 (acid phosphatase 4). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pho-8 in Genome Data Viewer
Location:
chromosome: V
Exon count:
7
Sequence:
Chromosome: V; NC_003283.11 (11833619..11835708)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ABC1 atypical kinase-like domain-containing protein Neighboring gene ncRNA Neighboring gene Nematode cuticle collagen N-terminal domain-containing protein Neighboring gene uncharacterized protein Neighboring gene Uncharacterized protein Neighboring gene Intrinsically Disordered Protein, class B

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A systems biology analysis of reproductive toxicity effects induced by multigenerational exposure to ionizing radiation in C. elegans. Guédon R, et al. Ecotoxicol Environ Saf, 2021 Dec 1. PMID 34544019
  2. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables phosphatase activity IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
intestinal acid PHOsphatase
NP_505983.2
  • Product from WormBase gene class pho;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    11833619..11835708
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073582.5 → NP_505983.2  intestinal acid PHOsphatase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_505983.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    P90949
    Conserved Domains (1) summary
    cd07061
    Location:21 → 327
    HP_HAP_like; Histidine phosphatase domain found in histidine acid phosphatases and phytases; contains a His residue which is phosphorylated during the reaction
Nucleotide Protein
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