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cyl-1 Cyclin L homolog cyl-1 [ Caenorhabditis elegans ]

Gene ID: 179643, updated on 2-Nov-2024

Summary

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Official Symbol
cyl-1
Official Full Name
Cyclin L homolog cyl-1
Primary source
WormBase:WBGene00000876
Locus tag
CELE_C52E4.6
See related
AllianceGenome:WB:WBGene00000876
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable cyclin-dependent protein serine/threonine kinase regulator activity. Acts upstream of or within nematode male tail tip morphogenesis. Predicted to be active in nucleus. Orthologous to several human genes including CCNL1 (cyclin L1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cyl-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
9
Sequence:
Chromosome: V; NC_003283.11 (11991011..11993723, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Histidine kinase Neighboring gene Essential MCU regulator, mitochondrial Neighboring gene Soluble guanylate cyclase gcy-33;guanylate cyclase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. CDK-11-Cyclin L is required for gametogenesis and fertility in C. elegans. Williams CW, et al. Dev Biol, 2018 Sep 1. PMID 29886128, Free PMC Article
  2. The L-type cyclin CYL-1 and the heat-shock-factor HSF-1 are required for heat-shock-induced protein expression in Caenorhabditis elegans. Hajdu-Cronin YM, et al. Genetics, 2004 Dec. PMID 15611166, Free PMC Article
  3. cdc-25.2, a Caenorhabditis elegans ortholog of cdc25, is required for male tail morphogenesis. Oh S, et al. Biochem Biophys Res Commun, 2017 Jan 22. PMID 27923661
  4. Caenorhabditis elegans AF4/FMR2 Family Homolog affl-2 Regulates Heat-Shock-Induced Gene Expression. Walton SJ, et al. Genetics, 2020 Aug. PMID 32518061, Free PMC Article
  5. Discovery of novel alternatively spliced C. elegans transcripts by computational analysis of SAGE data. Ruzanov P, et al. BMC Genomics, 2007 Nov 30. PMID 18053145, Free PMC Article

See all (11) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
acts_upstream_of_or_within nematode male tail tip morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Cyclin L homolog cyl-1
NP_506007.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    11991011..11993723 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073606.6 → NP_506007.1  Cyclin L homolog cyl-1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506007.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G5EBX3
    Conserved Domains (2) summary
    cd20532
    Location:95 → 230
    CYCLIN_CCNL_rpt1; first cyclin box found in cyclin-L (CCNL) family
    cd20533
    Location:235 → 330
    CYCLIN_CCNL_rpt2; second cyclin box found in cyclin-L (CCNL) family

RNA

  1. NR_001507.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
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