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gcy-33 Soluble guanylate cyclase gcy-33;guanylate cyclase [ Caenorhabditis elegans ]

Gene ID: 179644, updated on 2-Nov-2024

Summary

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Official Symbol
gcy-33
Official Full Name
Soluble guanylate cyclase gcy-33;guanylate cyclase
Primary source
WormBase:WBGene00001553
Locus tag
CELE_F57F5.2
See related
AllianceGenome:WB:WBGene00001553
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables carbon monoxide sensor activity; nitric oxide binding activity; and oxygen sensor activity. Involved in chemosensory behavior; response to oxygen levels; and sensory perception of bitter taste. Predicted to be located in cytoplasm. Predicted to be part of guanylate cyclase complex, soluble. Is expressed in oxygen sensory neurons. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gcy-33 in Genome Data Viewer
Location:
chromosome: V
Exon count:
11
Sequence:
Chromosome: V; NC_003283.11 (11995805..12001797, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Cyclin L homolog cyl-1 Neighboring gene Histidine kinase Neighboring gene Essential MCU regulator, mitochondrial Neighboring gene ncRNA Neighboring gene tRNA-Ile Neighboring gene ncRNA Neighboring gene Peptidase C1A papain C-terminal domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Probing domain interactions in soluble guanylate cyclase. Derbyshire ER, et al. Biochemistry, 2011 May 24. PMID 21491957, Free PMC Article
  2. A single amino acid change in the EGL-46 transcription factor causes defects in BAG neuron specification. Godini R, et al. MicroPubl Biol, 2020 Feb 25. PMID 32550488, Free PMC Article
  3. Guanylate cyclases link serotoninergic signaling to modulate ethanol-induced food intake in C. elegans. Wang X, et al. Biochem Biophys Res Commun, 2021 Aug 27. PMID 34133999
  4. New insights on the functions of the guanylyl cyclase receptors. Wedel BJ, et al. FEBS Lett, 1997 Jun 23. PMID 9247117
  5. Oxygen-sensing neurons reciprocally regulate peripheral lipid metabolism via neuropeptide signaling in Caenorhabditis elegans. Hussey R, et al. PLoS Genet, 2018 Mar. PMID 29579048, Free PMC Article

See all (31) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables GTP binding IEA
Inferred from Electronic Annotation
more info
  
enables carbon monoxide sensor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables guanylate cyclase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables guanylate cyclase activity IEA
Inferred from Electronic Annotation
more info
  
enables heme binding IEA
Inferred from Electronic Annotation
more info
  
enables lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables nitric oxide binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nitric oxide binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxygen sensor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables oxygen sensor activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables oxygen sensor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Process Evidence Code Pubs
involved_in cGMP biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in chemosensory behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in chemosensory behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cyclic nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in nitric oxide-cGMP-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to oxygen levels IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in response to oxygen levels IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in sensory perception of bitter taste IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in sensory perception of bitter taste IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
part_of guanylate cyclase complex, soluble IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Soluble guanylate cyclase gcy-33;guanylate cyclase
NP_001256391.1
  • Confirmed by transcript evidence
NP_001256392.1
  • Partially confirmed by transcript evidence
NP_001256393.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    11995805..12001797 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001269462.4 → NP_001256391.1  Soluble guanylate cyclase gcy-33 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256391.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P90895, Q18791, Q86C59
    Conserved Domains (6) summary
    smart00044
    Location:400 → 596
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    COG5134
    Location:593 → 742
    COG5134; Uncharacterized conserved protein [Function unknown]
    pfam07700
    Location:2 → 164
    HNOB; Haem-NO-binding
    pfam07701
    Location:204 → 421
    HNOBA; Heme NO binding associated
    pfam17084
    Location:708 → 896
    TDA11; Topoisomerase I damage affected protein 11
    cl11967
    Location:431 → 616
    Nucleotidyl_cyc_III; Class III nucleotidyl cyclases

  2. NM_001269463.3 → NP_001256392.1  guanylate cyclase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256392.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H2L2D1
    Conserved Domains (5) summary
    smart00044
    Location:402 → 598
    CYCc; Adenylyl- / guanylyl cyclase, catalytic domain
    COG5134
    Location:595 → 744
    COG5134; Uncharacterized conserved protein [Function unknown]
    pfam17084
    Location:710 → 898
    TDA11; Topoisomerase I damage affected protein 11
    pfam07701
    Location:204 → 423
    HNOBA; Heme NO binding associated
    pfam07700
    Location:2 → 164
    HNOB; Haem-NO-binding

  3. NM_001269464.3 → NP_001256393.1  Soluble guanylate cyclase gcy-33 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256393.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EGJ1
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P90895.4

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