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F10C2.5 alpha-1,2-Mannosidase [ Caenorhabditis elegans ]

Gene ID: 179653, updated on 2-Nov-2024

Summary

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Official Symbol
F10C2.5
Official Full Name
alpha-1,2-Mannosidase
Primary source
WormBase:WBGene00008646
Locus tag
CELE_F10C2.5
See related
AllianceGenome:WB:WBGene00008646
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable calcium ion binding activity and mannosyl-oligosaccharide 1,2-alpha-mannosidase activity. Predicted to be involved in endoplasmic reticulum unfolded protein response; mannoprotein catabolic process; and ubiquitin-dependent glycoprotein ERAD pathway. Predicted to be located in membrane. Predicted to be active in endoplasmic reticulum. Is expressed in several structures, including body wall musculature; intestine; neurons; pharyngeal cell; and vulval muscle. Orthologous to human EDEM2 (ER degradation enhancing alpha-mannosidase like protein 2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See F10C2.5 in Genome Data Viewer
Location:
chromosome: V
Exon count:
6
Sequence:
Chromosome: V; NC_003283.11 (12045432..12048631)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Protein kup-1 Neighboring gene ncRNA Neighboring gene DNA polymerase delta catalytic subunit Neighboring gene Aminoacyl-transfer RNA synthetases class-II family profile domain-containing protein Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Evidence of glutathione transferase complexing and signaling in the model nematode Caenorhabditis elegans using a pull-down proteomic assay. Greetham D, et al. Proteomics, 2004 Jul. PMID 15221760
  2. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables calcium ion binding IEA
Inferred from Electronic Annotation
more info
  
enables hydrolase activity, acting on glycosyl bonds IEA
Inferred from Electronic Annotation
more info
  
enables mannosyl-oligosaccharide 1,2-alpha-mannosidase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in carbohydrate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum mannose trimming IEA
Inferred from Electronic Annotation
more info
  
involved_in endoplasmic reticulum unfolded protein response IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mannoprotein catabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mannose trimming involved in glycoprotein ERAD pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in ubiquitin-dependent glycoprotein ERAD pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in endoplasmic reticulum IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
alpha-1,2-Mannosidase
NP_506018.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    12045432..12048631
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073617.6 → NP_506018.1  alpha-1,2-Mannosidase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506018.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    P90830
    Conserved Domains (1) summary
    pfam01532
    Location:49 → 489
    Glyco_hydro_47; Glycosyl hydrolase family 47
Nucleotide Protein
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