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clh-6 Chloride channel protein [ Caenorhabditis elegans ]

Gene ID: 179655, updated on 2-Nov-2024

Summary

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Official Symbol
clh-6
Official Full Name
Chloride channel protein
Primary source
WormBase:WBGene00000533
Locus tag
CELE_R07B7.1
See related
AllianceGenome:WB:WBGene00000533
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable chloride transmembrane transporter activity. Involved in lysosomal protein catabolic process. Predicted to be located in membrane. Predicted to be active in lysosomal membrane. Is expressed in several structures, including excretory cell; neurons; pharyngeal-intestinal valve; pharynx; and reproductive system. Human ortholog(s) of this gene implicated in autosomal dominant osteopetrosis 2 and autosomal recessive osteopetrosis 4. Orthologous to human CLCN7 (chloride voltage-gated channel 7). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See clh-6 in Genome Data Viewer
Location:
chromosome: V
Exon count:
10
Sequence:
Chromosome: V; NC_003283.11 (12060234..12063368, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Major facilitator superfamily (MFS) profile domain-containing protein Neighboring gene PUM-HD domain-containing protein Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene ncRNA Neighboring gene FAD-binding domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of a novel voltage-dependent outwardly rectifying anion current in Caenorhabditis elegans oocytes. Yin X, et al. Am J Physiol Cell Physiol, 2007 Jan. PMID 16899547
  2. Expression of a CIC chloride channel in Caenorhabditis elegans gamma-aminobutyric acid-ergic neurons. Bianchi L, et al. Neurosci Lett, 2001 Feb 23. PMID 11165764
  3. Into ion channel and transporter function. Caenorhabditis elegans ClC-type chloride channels: novel variants and functional expression. Nehrke K, et al. Am J Physiol Cell Physiol, 2000 Dec. PMID 11078724
  4. CLC Chloride Channels and Transporters: Structure, Function, Physiology, and Disease. Jentsch TJ, et al. Physiol Rev, 2018 Jul 1. PMID 29845874
  5. Regulators of Lysosome Function and Dynamics in Caenorhabditis elegans. Gee K, et al. G3 (Bethesda), 2017 Mar 10. PMID 28122949, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Lysosomal chloride transporter CLH-6 protects lysosome membrane integrity via cathepsin activation.
    Title: Lysosomal chloride transporter CLH-6 protects lysosome membrane integrity via cathepsin activation.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables chloride transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables voltage-gated chloride channel activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in chloride transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in chloride transport IEA
Inferred from Electronic Annotation
more info
  
involved_in lysosomal protein catabolic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in monoatomic ion transport IEA
Inferred from Electronic Annotation
more info
  
involved_in transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in intracellular membrane-bounded organelle IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in lysosomal membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in lysosomal membrane ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Chloride channel protein
NP_506022.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    12060234..12063368 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073621.6 → NP_506022.1  Chloride channel protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506022.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EC75
    Conserved Domains (3) summary
    cd03685
    Location:70 → 598
    ClC_6_like; ClC-6-like chloride channel proteins. This CD includes ClC-6, ClC-7 and ClC-B, C, D in plants. Proteins in this family are ubiquitous in eukarotes and their functions are unclear. They are expressed in intracellular organelles membranes. This family ...
    cd04591
    Location:620 → 774
    CBS_pair_EriC_assoc_euk_bac; This cd contains two tandem repeats of the cystathionine beta-synthase (CBS pair) domains in the EriC CIC-type chloride channels in eukaryotes and bacteria. These ion channels are proteins with a seemingly simple task of allowing the passive flow of ...
    pfam00654
    Location:168 → 580
    Voltage_CLC; Voltage gated chloride channel
Nucleotide Protein
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