U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

kmo-1 Kynurenine 3-monooxygenase [ Caenorhabditis elegans ]

Gene ID: 179657, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
kmo-1
Official Full Name
Kynurenine 3-monooxygenase
Primary source
WormBase:WBGene00011089
Locus tag
CELE_R07B7.5
See related
AllianceGenome:WB:WBGene00011089
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable kynurenine 3-monooxygenase activity. Predicted to be involved in NAD metabolic process and kynurenine metabolic process. Predicted to be located in mitochondrial membrane. Predicted to be active in mitochondrial outer membrane. Human ortholog(s) of this gene implicated in schizophrenia. Orthologous to human KMO (kynurenine 3-monooxygenase). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See kmo-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
8
Sequence:
Chromosome: V; NC_003283.11 (12068724..12070519, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene ncRNA Neighboring gene FAD-binding domain-containing protein Neighboring gene Nucleotid_trans domain-containing protein Neighboring gene ncRNA Neighboring gene Lipase_GDSL domain-containing protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Delaying aging and the aging-associated decline in protein homeostasis by inhibition of tryptophan degradation. van der Goot AT, et al. Proc Natl Acad Sci U S A, 2012 Sep 11. PMID 22927396, Free PMC Article
  2. Bacterial diet affects the age-dependent decline of associative learning in Caenorhabditis elegans. Higurashi S, et al. Elife, 2023 May 30. PMID 37252859, Free PMC Article
  3. Kynurenic acid is a nutritional cue that enables behavioral plasticity. Lemieux GA, et al. Cell, 2015 Jan 15. PMID 25594177, Free PMC Article
  4. FMO rewires metabolism to promote longevity through tryptophan and one carbon metabolism in C. elegans. Choi HS, et al. Nat Commun, 2023 Feb 2. PMID 36732543, Free PMC Article
  5. The conserved histone chaperone LIN-53 is required for normal lifespan and maintenance of muscle integrity in Caenorhabditis elegans. Müthel S, et al. Aging Cell, 2019 Dec. PMID 31397537, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

Go to the top of the page

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables FAD binding IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables kynurenine 3-monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables kynurenine 3-monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables kynurenine 3-monooxygenase activity ISS
Inferred from Sequence or Structural Similarity
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in 'de novo' NAD biosynthetic process from tryptophan IEA
Inferred from Electronic Annotation
more info
  
involved_in NAD biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in NAD metabolic process ISS
Inferred from Sequence or Structural Similarity
more info
  
involved_in anthranilate metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in kynurenine metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in pyridine nucleotide biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in quinolinate biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in tryptophan catabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrial outer membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrial outer membrane ISS
Inferred from Sequence or Structural Similarity
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Kynurenine 3-monooxygenase
NP_506025.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    12068724..12070519 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073624.7 → NP_506025.1  Kynurenine 3-monooxygenase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506025.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q21795
    Conserved Domains (2) summary
    COG0644
    Location:4 → 436
    FixC; Dehydrogenase (flavoprotein) [Energy production and conversion]
    cl21454
    Location:4 → 363
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q21795.1

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Chemical Information
Molecular Biology Databases
Research Materials
Tools
Miscellaneous