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enpp-1 Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1;NUC domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 179663, updated on 2-Nov-2024

Summary

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Official Symbol
enpp-1
Official Full Name
Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1;NUC domain-containing protein
Primary source
WormBase:WBGene00007753
Locus tag
CELE_C27A7.1
See related
AllianceGenome:WB:WBGene00007753
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable hydrolase activity. Predicted to be located in membrane. Predicted to be active in I band and striated muscle dense body. Is expressed in ciliated neurons; pharynx; and vas deferens cuboidal cell. Human ortholog(s) of this gene implicated in several diseases, including arterial calcification of infancy; end stage renal disease; obesity; ossification of the posterior longitudinal ligament of spine; and type 2 diabetes mellitus. Orthologous to human ENPP1 (ectonucleotide pyrophosphatase/phosphodiesterase 1); ENPP2 (ectonucleotide pyrophosphatase/phosphodiesterase 2); and ENPP3 (ectonucleotide pyrophosphatase/phosphodiesterase 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See enpp-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
16
Sequence:
Chromosome: V; NC_003283.11 (12131457..12137395)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene MFS domain-containing protein Neighboring gene MFS domain-containing protein Neighboring gene ncRNA Neighboring gene pseudo Neighboring gene Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1;Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.3 Neighboring gene WD_REPEATS_REGION domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Isolation, profiling, and tracking of extracellular vesicle cargo in Caenorhabditis elegans. Nikonorova IA, et al. Curr Biol, 2022 May 9. PMID 35334227, Free PMC Article
  2. Cilia-Derived Extracellular Vesicles in Caenorhabditis Elegans: In Vivo Imaging and Quantification of Extracellular Vesicle Release and Capture. Razzauti A, et al. Methods Mol Biol, 2023. PMID 37140803
  3. C30F12.4 influences oogenesis, fat metabolism, and lifespan in C. elegans. Wang L, et al. Protein Cell, 2016 Oct. PMID 27638466, Free PMC Article
  4. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
  5. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in I band IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in striated muscle dense body IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1;NUC domain-containing protein
NP_001041085.1
  • Confirmed by transcript evidence
NP_001041086.1
  • Confirmed by transcript evidence
NP_001129885.1
  • Confirmed by transcript evidence
NP_001256405.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    12131457..12137395
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001047620.4 → NP_001041085.1  Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001041085.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P90754, Q2PJ70
    Conserved Domains (2) summary
    pfam01663
    Location:182 → 494
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
    cd16018
    Location:180 → 534
    Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

  2. NM_001047621.3 → NP_001041086.1  Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001041086.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P90754
    Conserved Domains (2) summary
    pfam01663
    Location:177 → 489
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
    cd16018
    Location:175 → 529
    Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

  3. NM_001269476.3 → NP_001256405.1  Ectonucleotide pyrophosphatase/phosphodiesterase C27A7.1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256405.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1B6U2
    Conserved Domains (2) summary
    pfam01663
    Location:168 → 480
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
    cd16018
    Location:166 → 520
    Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin

  4. NM_001136413.4 → NP_001129885.1  NUC domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001129885.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B5BM33
    Conserved Domains (2) summary
    pfam01663
    Location:119 → 431
    Phosphodiest; Type I phosphodiesterase / nucleotide pyrophosphatase
    cd16018
    Location:117 → 471
    Enpp; Ectonucleotide pyrophosphatase/phosphodiesterase, also called autotaxin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P90754.1

Gene LinkOut

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