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tsfm-1 Elongation factor Ts, mitochondrial [ Caenorhabditis elegans ]

Gene ID: 179683, updated on 2-Nov-2024

Summary

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Official Symbol
tsfm-1
Official Full Name
Elongation factor Ts, mitochondrial
Primary source
WormBase:WBGene00010094
Locus tag
CELE_F55C5.5
See related
AllianceGenome:WB:WBGene00010094
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable translation elongation factor activity. Predicted to be involved in mitochondrial translational elongation. Predicted to be located in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 3. Orthologous to human TSFM (Ts translation elongation factor, mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See tsfm-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
4
Sequence:
Chromosome: V; NC_003283.11 (12270271..12271551, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene Potassium channel domain-containing protein Neighboring gene CAP-G condensin subunit Neighboring gene Basonuclin zinc finger protein homolog Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of the interaction between the nucleotide exchange factor EF-Ts from nematode mitochondria and elongation factor Tu. Ohtsuki T, et al. Nucleic Acids Res, 2002 Dec 15. PMID 12490713, Free PMC Article
  2. The chromatin factors SET-26 and HCF-1 oppose the histone deacetylase HDA-1 in longevity and gene regulation in C. elegans. Emerson FJ, et al. Nat Commun, 2024 Mar 14. PMID 38485937, Free PMC Article
  3. Identification of conserved pathways of DNA-damage response and radiation protection by genome-wide RNAi. van Haaften G, et al. Curr Biol, 2006 Jul 11. PMID 16824923
  4. Dynein modifiers in C. elegans: light chains suppress conditional heavy chain mutants. O'Rourke SM, et al. PLoS Genet, 2007 Aug. PMID 17676955, Free PMC Article
  5. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article

See all (9) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables translation elongation factor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables translation elongation factor activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in mitochondrial translational elongation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in translation IEA
Inferred from Electronic Annotation
more info
  
involved_in translational elongation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Elongation factor Ts, mitochondrial
NP_506079.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    12270271..12271551 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073678.6 → NP_506079.1  Elongation factor Ts, mitochondrial [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506079.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q20819
    Conserved Domains (3) summary
    PRK12332
    Location:25 → 187
    tsf; elongation factor Ts; Reviewed
    cd14275
    Location:28 → 65
    UBA_EF-Ts; UBA domain found in elongation factor Ts (EF-Ts) from bacteria, chloroplasts and mitochondria of eukaryotes
    pfam00889
    Location:97 → 314
    EF_TS; Elongation factor TS
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q20819.1

Gene LinkOut

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