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frm-7 FERM domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 179687, updated on 2-Nov-2024

Summary

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Official Symbol
frm-7
Official Full Name
FERM domain-containing protein
Primary source
WormBase:WBGene00001493
Locus tag
CELE_C51F7.1
See related
AllianceGenome:WB:WBGene00001493
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in positive regulation of hippo signaling. Predicted to be active in cytoplasmic side of apical plasma membrane. Orthologous to several human genes including FRMD1 (FERM domain containing 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See frm-7 in Genome Data Viewer
Location:
chromosome: V
Exon count:
10
Sequence:
Chromosome: V; NC_003283.11 (12302484..12306974)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Serpentine receptor class gamma Neighboring gene Clc-like protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The C. elegans ezrin-radixin-moesin protein ERM-1 is necessary for apical junction remodelling and tubulogenesis in the intestine. Van Fürden D, et al. Dev Biol, 2004 Aug 1. PMID 15242805
  2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in positive regulation of hippo signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in cytoplasmic side of apical plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
FERM domain-containing protein
NP_506085.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    12302484..12306974
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073684.6 → NP_506085.2  FERM domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506085.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XXK4
    Conserved Domains (2) summary
    smart00295
    Location:45 → 269
    B41; Band 4.1 homologues
    cd13185
    Location:257 → 362
    FERM_C_FRMD1_FRMD6; FERM domain C-lobe of FERM domain containing 1 and 6 proteins
Nucleotide Protein
Heading Accession and Version

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