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twk-14 Potassium channel domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 179699, updated on 2-Nov-2024

Summary

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Official Symbol
twk-14
Official Full Name
Potassium channel domain-containing protein
Primary source
WormBase:WBGene00006669
Locus tag
CELE_K01D12.4
See related
AllianceGenome:WB:WBGene00006669
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable outward rectifier potassium channel activity and potassium ion leak channel activity. Predicted to be involved in potassium ion transmembrane transport. Predicted to be located in membrane. Predicted to be part of monoatomic ion channel complex. Predicted to be active in plasma membrane. Orthologous to several human genes including KCNK12 (potassium two pore domain channel subfamily K member 12). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See twk-14 in Genome Data Viewer
Location:
chromosome: V
Exon count:
10
Sequence:
Chromosome: V; NC_003283.11 (12387039..12395706, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene DNA-binding protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene MItoGuArdin homolog Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Structure and function of two-pore-domain K+ channels: contributions from genetic model organisms. Buckingham SD, et al. Trends Pharmacol Sci, 2005 Jul. PMID 15939489
  2. A map of the interactome network of the metazoan C. elegans. Li S, et al. Science, 2004 Jan 23. PMID 14704431, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables outward rectifier potassium channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables potassium channel activity IEA
Inferred from Electronic Annotation
more info
  
enables potassium ion leak channel activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in monoatomic ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in potassium ion transmembrane transport IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in potassium ion transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
part_of monoatomic ion channel complex IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Potassium channel domain-containing protein
NP_001263870.1
  • Confirmed by transcript evidence
NP_001366791.1
  • Confirmed by transcript evidence
NP_001367281.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    12387039..12395706 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001276941.4 → NP_001263870.1  Potassium channel domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001263870.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    I2HAG5
    Conserved Domains (1) summary
    pfam07885
    Location:137 → 196
    Ion_trans_2; Ion channel

  2. NM_001380785.1 → NP_001366791.1  Potassium channel domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q21094
    Conserved Domains (1) summary
    pfam07885
    Location:124 → 183
    Ion_trans_2; Ion channel

  3. NM_001380784.1 → NP_001367281.1  Potassium channel domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    F5GUD1
    Conserved Domains (1) summary
    pfam07885
    Location:149 → 208
    Ion_trans_2; Ion channel
Nucleotide Protein
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