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hrg-9 Transport and Golgi organization protein 2 homolog [ Caenorhabditis elegans ]

Gene ID: 179780, updated on 2-Nov-2024

Summary

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Official Symbol
hrg-9
Official Full Name
Transport and Golgi organization protein 2 homolog
Primary source
WormBase:WBGene00011305
Locus tag
CELE_R186.1
See related
AllianceGenome:WB:WBGene00011305
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in Golgi organization and protein secretion. Predicted to be active in Golgi apparatus. Is expressed in intestine. Used to study chromosome 22q11.2 deletion syndrome, distal. Human ortholog(s) of this gene implicated in TANGO2-related metabolic encephalopathy and arrythmias. Orthologous to human TANGO2 (transport and golgi organization 2 homolog). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hrg-9 in Genome Data Viewer
Location:
chromosome: V
Exon count:
5
Sequence:
Chromosome: V; NC_003283.11 (12961474..12963343, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene D-aminoacyl-tRNA deacylase Neighboring gene Eukaryotic translation initiation factor 3 subunit K Neighboring gene Rhodanese domain-containing protein Neighboring gene ncRNA Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein;Serpentine Receptor, class D (delta) Neighboring gene Signal recognition particle receptor subunit beta

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. HRG-9 homologues regulate haem trafficking from haem-enriched compartments. Sun F, et al. Nature, 2022 Oct. PMID 36261532, Free PMC Article
  2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HRG-9 homologues regulate haem trafficking from haem-enriched compartments.
    Title: HRG-9 homologues regulate haem trafficking from haem-enriched compartments.
Submit: New GeneRIF Correction

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in Golgi organization IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in protein secretion IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in Golgi apparatus IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Transport and Golgi organization protein 2 homolog
NP_506243.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    12961474..12963343 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073842.4 → NP_506243.1  Transport and Golgi organization protein 2 homolog [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506243.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q22009
    Conserved Domains (1) summary
    pfam05742
    Location:1 → 259
    TANGO2; Transport and Golgi organization 2
Nucleotide Protein
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