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lin-46 MoeA N-terminal and linker domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 179782, updated on 2-Nov-2024

Summary

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Official Symbol
lin-46
Official Full Name
MoeA N-terminal and linker domain-containing protein
Primary source
WormBase:WBGene00003031
Locus tag
CELE_R186.4
See related
AllianceGenome:WB:WBGene00003031
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable molecular adaptor activity and molybdopterin molybdotransferase activity. Involved in regulation of development, heterochronic. Located in cytoplasm and nucleus. Is expressed in hypodermis and vulval precursor cell. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See lin-46 in Genome Data Viewer
Location:
chromosome: V
Exon count:
5
Sequence:
Chromosome: V; NC_003283.11 (12968855..12970730)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Signal recognition particle receptor subunit beta Neighboring gene 39S ribosomal protein L33, mitochondrial Neighboring gene Pinin/SDK/MemA protein domain-containing protein Neighboring gene BTB domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Regulation of nuclear-cytoplasmic partitioning by the lin-28-lin-46 pathway reinforces microRNA repression of HBL-1 to confer robust cell-fate progression in C. elegans. Ilbay O, et al. Development, 2019 Nov 6. PMID 31597658, Free PMC Article
  2. C. elegans LIN-28 controls temporal cell fate progression by regulating LIN-46 expression via the 5' UTR of lin-46 mRNA. Ilbay O, et al. Cell Rep, 2021 Sep 7. PMID 34496246, Free PMC Article
  3. Regulatory mutations of mir-48, a C. elegans let-7 family MicroRNA, cause developmental timing defects. Li M, et al. Dev Cell, 2005 Sep. PMID 16139229
  4. Novel heterochronic functions of the Caenorhabditis elegans period-related protein LIN-42. Tennessen JM, et al. Dev Biol, 2006 Jan 1. PMID 16300753
  5. Heterochronic genes and the temporal control of C. elegans development. Ambros V, et al. Trends Genet, 1994 Apr. PMID 8029828

See all (26) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. robust progression from L2 to L3 cell fates depends on the combination of two distinct modes of HBL-1 downregulation: decreased synthesis of HBL-1 via let-7-family microRNA activity, and decreased nuclear accumulation of HBL-1 via action of the lin-28-lin-46 pathway
    Title: Regulation of nuclear-cytoplasmic partitioning by the lin-28-lin-46 pathway reinforces microRNA repression of HBL-1 to confer robust cell-fate progression in C. elegans.
  2. Data suggest that the LIN-46 protein acts as a scaffold for a multiprotein assembly that controls developmental timing, and expand the known roles of gephyrin-related proteins to development.
    Title: The C. elegans heterochronic gene lin-46 affects developmental timing at two larval stages and encodes a relative of the scaffolding protein gephyrin.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables molecular adaptor activity ISS
Inferred from Sequence or Structural Similarity
more info
 PubMed 
enables molybdopterin adenylyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables molybdopterin molybdotransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables molybdopterin molybdotransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables transferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in Mo-molybdopterin cofactor biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in Mo-molybdopterin cofactor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in establishment of synaptic specificity at neuromuscular junction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in gamma-aminobutyric acid receptor clustering IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in glycine receptor clustering IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in molybdopterin cofactor biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in postsynaptic neurotransmitter receptor diffusion trapping IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of development, heterochronic IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in dendrite IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in postsynaptic membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in postsynaptic specialization IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in postsynaptic specialization membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
MoeA N-terminal and linker domain-containing protein
NP_506246.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    12968855..12970730
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073845.5 → NP_506246.1  MoeA N-terminal and linker domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506246.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EF06
    Conserved Domains (1) summary
    cd00887
    Location:27 → 387
    MoeA; MoeA family. Members of this family are involved in biosynthesis of the molybdenum cofactor (MoCF), an essential cofactor of a diverse group of redox enzymes. MoCF biosynthesis is an evolutionarily conserved pathway present in eubacteria, archaea and ...
Nucleotide Protein
Heading Accession and Version

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