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inft-2 FH2 domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 179786, updated on 2-Nov-2024

Summary

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Official Symbol
inft-2
Official Full Name
FH2 domain-containing protein
Primary source
WormBase:WBGene00008848
Locus tag
CELE_F15B9.4
See related
AllianceGenome:WB:WBGene00008848
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in actin filament polymerization. Predicted to be active in actin filament. Is expressed in excretory cell. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See inft-2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
11
Sequence:
Chromosome: V; NC_003283.11 (13002317..13006987)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Fatty-acid and retinol-binding protein 1 Neighboring gene Fatty-acid and retinol-binding protein 1 Neighboring gene DUF148 domain-containing protein Neighboring gene ncRNA Neighboring gene tRNA-Ala Neighboring gene TPM domain-containing protein Neighboring gene Peptidase S1 domain-containing protein Neighboring gene ncRNA Neighboring gene Uncharacterized protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A network of conserved formins, regulated by the guanine exchange factor EXC-5 and the GTPase CDC-42, modulates tubulogenesis in vivo. Shaye DD, et al. Development, 2016 Nov 15. PMID 27697907, Free PMC Article
  2. Z-line formins promote contractile lattice growth and maintenance in striated muscles of C. elegans. Mi-Mi L, et al. J Cell Biol, 2012 Jul 9. PMID 22753896, Free PMC Article
  3. FHOD-1 is the only formin in Caenorhabditis elegans that promotes striated muscle growth and Z-line organization in a cell autonomous manner. Sundaramurthy S, et al. Cytoskeleton (Hoboken), 2020 Oct. PMID 33103378, Free PMC Article
  4. Functional importance of an inverted formin C-terminal tail at morphologically dynamic epithelial junctions. Hegsted A, et al. Cytoskeleton (Hoboken), 2019 Apr. PMID 31215743, Free PMC Article
  5. SH3 interactome conserves general function over specific form. Xin X, et al. Mol Syst Biol, 2013. PMID 23549480, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in actin filament polymerization IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
is_active_in actin filament IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
FH2 domain-containing protein
NP_506253.4
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    13002317..13006987
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073852.9 → NP_506253.4  FH2 domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506253.4

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q19479
    Conserved Domains (1) summary
    cl19758
    Location:597 → 975
    FH2; Formin Homology 2 Domain
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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