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scyl-1 Protein kinase domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 179789, updated on 2-Nov-2024

Summary

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Official Symbol
scyl-1
Official Full Name
Protein kinase domain-containing protein
Primary source
WormBase:WBGene00012337
Locus tag
CELE_W07G4.3
See related
AllianceGenome:WB:WBGene00012337
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable kinase activity. Is expressed in excretory cell; intestinal cell; spermatheca; uterine epithelial cell; and ventral cord neurons. Human ortholog(s) of this gene implicated in autosomal recessive spinocerebellar ataxia 21. Orthologous to human SCYL1 (SCY1 like pseudokinase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See scyl-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
10
Sequence:
Chromosome: V; NC_003283.11 (13036894..13041721, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene FIP (Fungus-Induced Protein) Related Neighboring gene Secretory peptide Neighboring gene L-Fucosyltransferase Neighboring gene ncRNA Neighboring gene Putative aminopeptidase W07G4.4

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Slo2 potassium channel function depends on RNA editing-regulated expression of a SCYL1 protein. Niu LG, et al. Elife, 2020 Apr 21. PMID 32314960, Free PMC Article
  2. Dissection of the mammalian midbody proteome reveals conserved cytokinesis mechanisms. Skop AR, et al. Science, 2004 Jul 2. PMID 15166316, Free PMC Article
  3. Genomic overview of protein kinases. Manning G. WormBook, 2005 Dec 13. PMID 18050405, Free PMC Article
  4. RNA targets and specificity of Staufen, a double-stranded RNA-binding protein in Caenorhabditis elegans. LeGendre JB, et al. J Biol Chem, 2013 Jan 25. PMID 23195953, Free PMC Article
  5. A combined binary interaction and phenotypic map of C. elegans cell polarity proteins. Koorman T, et al. Nat Cell Biol, 2016 Mar. PMID 26780296, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables kinase activity IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Protein kinase domain-containing protein
NP_001366843.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    13036894..13041721 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001380793.3 → NP_001366843.1  Protein kinase domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q23215
    Conserved Domains (3) summary
    sd00044
    Location:313 → 337
    HEAT; HEAT repeat [structural motif]
    pfam13513
    Location:446 → 492
    HEAT_EZ; HEAT-like repeat
    cl21453
    Location:58 → 165
    PKc_like; Protein Kinases, catalytic domain
Nucleotide Protein
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