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max-1 PH domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 179794, updated on 2-Nov-2024

Summary

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Official Symbol
max-1
Official Full Name
PH domain-containing protein
Primary source
WormBase:WBGene00003143
Locus tag
CELE_C34B4.1
See related
AllianceGenome:WB:WBGene00003143
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in motor neuron axon guidance. Predicted to be located in cytoskeleton. Is expressed in neurons. Orthologous to human PLEKHH1 (pleckstrin homology, MyTH4 and FERM domain containing H1) and PLEKHH2 (pleckstrin homology, MyTH4 and FERM domain containing H2). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See max-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
11
Sequence:
Chromosome: V; NC_003283.11 (13098914..13110337, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene pseudo Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Vertebrate MAX-1 is required for vascular patterning in zebrafish. Zhong H, et al. Proc Natl Acad Sci U S A, 2006 Nov 7. PMID 17065323, Free PMC Article
  2. Regulation of axon repulsion by MAX-1 SUMOylation and AP-3. Chen SY, et al. Proc Natl Acad Sci U S A, 2018 Aug 28. PMID 30104385, Free PMC Article
  3. The PH/MyTH4/FERM molecule MAX-1 inhibits UNC-5 activity in the regulation of VD growth cone protrusion in Caenorhabditis elegans. Mahadik SS, et al. Genetics, 2022 May 5. PMID 35348689, Free PMC Article
  4. Disrupted-in-Schizophrenia 1-mediated axon guidance involves TRIO-RAC-PAK small GTPase pathway signaling. Chen SY, et al. Proc Natl Acad Sci U S A, 2011 Apr 5. PMID 21422296, Free PMC Article
  5. The Caenorhabditis elegans P21-activated kinases are differentially required for UNC-6/netrin-mediated commissural motor axon guidance. Lucanic M, et al. Development, 2006 Nov. PMID 17050621

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in motor neuron axon guidance IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
PH domain-containing protein
NP_001367137.1
  • Confirmed by transcript evidence
NP_001379161.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    13098914..13110337 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001392634.1 → NP_001379161.1  PH domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q18420, Q8MTP4
    Conserved Domains (4) summary
    smart00233
    Location:249 → 346
    PH; Pleckstrin homology domain
    smart00295
    Location:677 → 892
    B41; Band 4.1 homologues
    pfam00784
    Location:558 → 662
    MyTH4; MyTH4 domain
    cl17171
    Location:888 → 984
    PH-like; Pleckstrin homology-like domain

  2. NM_001380794.1 → NP_001367137.1  PH domain-containing protein [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ED24, Q8MTP4
    Conserved Domains (4) summary
    smart00233
    Location:353 → 450
    PH; Pleckstrin homology domain
    smart00295
    Location:781 → 996
    B41; Band 4.1 homologues
    pfam00784
    Location:662 → 766
    MyTH4; MyTH4 domain
    cl17171
    Location:992 → 1088
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein
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