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gut-2 U6 snRNA-associated Sm-like protein LSm2 [ Caenorhabditis elegans ]

Gene ID: 179833, updated on 2-Nov-2024

Summary

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Official Symbol
gut-2
Official Full Name
U6 snRNA-associated Sm-like protein LSm2
Primary source
WormBase:WBGene00001808
Locus tag
CELE_T10G3.6
See related
AllianceGenome:WB:WBGene00001808
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to contribute to RNA binding activity. Predicted to be involved in mRNA splicing, via spliceosome. Predicted to be located in cytoplasm and nucleus. Predicted to be part of Lsm1-7-Pat1 complex and nucleus. Predicted to be active in P-body. Orthologous to human LSM2 (LSM2 homolog, U6 small nuclear RNA and mRNA degradation associated). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gut-2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
4
Sequence:
Chromosome: V; NC_003283.11 (13497690..13498819)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene C6 domain-containing protein Neighboring gene FYVE-type domain-containing protein Neighboring gene Ig-like domain-containing protein;Neurotransmitter-gated ion-channel transmembrane domain-containing protein Neighboring gene FIP (Fungus-Induced Protein) Related Neighboring gene tRNA-Pro

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. LSM2-8 and XRN-2 contribute to the silencing of H3K27me3-marked genes through targeted RNA decay. Mattout A, et al. Nat Cell Biol, 2020 May. PMID 32251399, Free PMC Article
  2. The ribonucleotidyl transferase USIP-1 acts with SART3 to promote U6 snRNA recycling. Rüegger S, et al. Nucleic Acids Res, 2015 Mar 31. PMID 25753661, Free PMC Article
  3. Novel LOTUS-domain proteins are organizational hubs that recruit C. elegans Vasa to germ granules. Cipriani PG, et al. Elife, 2021 Jul 5. PMID 34223818, Free PMC Article
  4. EPIC: software toolkit for elution profile-based inference of protein complexes. Hu LZ, et al. Nat Methods, 2019 Aug. PMID 31308550, Free PMC Article
  5. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article

See all (7) citations in PubMed

GeneRIFs: Gene References Into Functions

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
contributes_to RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in RNA splicing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA processing IEA
Inferred from Electronic Annotation
more info
  
involved_in mRNA splicing, via spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in mRNA splicing, via spliceosome IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of Lsm1-7-Pat1 complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in P-body IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U4/U6 x U5 tri-snRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of U6 snRNP IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of catalytic step 2 spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of precatalytic spliceosome IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of spliceosomal complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
U6 snRNA-associated Sm-like protein LSm2
NP_001256511.1
  • Confirmed by transcript evidence
NP_001256512.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    13497690..13498819
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001269582.2 → NP_001256511.1  U6 snRNA-associated Sm-like protein LSm2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256511.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    P92022
    Conserved Domains (1) summary
    cd01725
    Location:2 → 90
    LSm2; Like-Sm protein 2

  2. NM_001269583.3 → NP_001256512.1  U6 snRNA-associated Sm-like protein LSm2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256512.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    E1B6V1
    Conserved Domains (1) summary
    cl00259
    Location:1 → 53
    Sm_like; Sm and related proteins
Nucleotide Protein
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