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cav-2 Caveolin-2 [ Caenorhabditis elegans ]

Gene ID: 179838, updated on 2-Nov-2024

Summary

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Official Symbol
cav-2
Official Full Name
Caveolin-2
Primary source
WormBase:WBGene00000302
Locus tag
CELE_C56A3.7
See related
AllianceGenome:WB:WBGene00000302
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables lipid transporter activity. Involved in parturition and regulation of egg-laying behavior. Located in apical plasma membrane. Is expressed in hypodermis; intestine; nervous system; pharynx; and reproductive system. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cav-2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
10
Sequence:
Chromosome: V; NC_003283.11 (13557104..13559922)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Leucine-rich repeat-containing protein Neighboring gene EF-hand domain-containing protein Neighboring gene Phosphatidylinositol 4-kinase type 2 Neighboring gene Ground-like domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Overexpression of caveolins in Caenorhabditis elegans induces changes in egg-laying and fecundity. Parker S, et al. Commun Integr Biol, 2009 Sep. PMID 19907693, Free PMC Article
  2. Identification, sequence, and expression of an invertebrate caveolin gene family from the nematode Caenorhabditis elegans. Implications for the molecular evolution of mammalian caveolin genes. Tang Z, et al. J Biol Chem, 1997 Jan 24. PMID 8999956
  3. Post-synaptic GABA(A) receptors potentiate transmission by recruiting CaV2 channels to their inputs. Zhao J, et al. Cell Rep, 2023 Oct 31. PMID 37742192, Free PMC Article
  4. Caveolin-2 is required for apical lipid trafficking and suppresses basolateral recycling defects in the intestine of Caenorhabditis elegans. Parker S, et al. Mol Biol Cell, 2009 Mar. PMID 19158391, Free PMC Article
  5. CHE-14, a protein with a sterol-sensing domain, is required for apical sorting in C. elegans ectodermal epithelial cells. Michaux G, et al. Curr Biol, 2000 Sep 21. PMID 10996790

See all (13) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Post-synaptic GABAA receptors potentiate transmission by recruiting CaV2 channels to their inputs.
    Title: Post-synaptic GABA(A) receptors potentiate transmission by recruiting CaV2 channels to their inputs.
  2. CaV1 and CaV2 calcium channels mediate the release of distinct pools of synaptic vesicles.
    Title: CaV1 and CaV2 calcium channels mediate the release of distinct pools of synaptic vesicles.
  3. caveolin-2 is an integral component of the trafficking network in the intestinal cells of C. elegans
    Title: Caveolin-2 is required for apical lipid trafficking and suppresses basolateral recycling defects in the intestine of Caenorhabditis elegans.
Submit: New GeneRIF Correction

Pathways from PubChem

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General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables lipid transporter activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables molecular adaptor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in caveola assembly IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in caveola assembly IEA
Inferred from Electronic Annotation
more info
  
involved_in cell surface receptor signaling pathway TAS
Traceable Author Statement
more info
 PubMed 
involved_in lipid transport IEA
Inferred from Electronic Annotation
more info
  
involved_in parturition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of egg-laying behavior IGI
Inferred from Genetic Interaction
more info
 PubMed 
Component Evidence Code Pubs
located_in Golgi apparatus IEA
Inferred from Electronic Annotation
more info
  
located_in Golgi membrane IEA
Inferred from Electronic Annotation
more info
  
located_in apical plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in apical plasma membrane IEA
Inferred from Electronic Annotation
more info
  
colocalizes_with caveola IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in caveola IEA
Inferred from Electronic Annotation
more info
  
located_in caveola TAS
Traceable Author Statement
more info
 PubMed 
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Caveolin-2
NP_001256523.1
  • Confirmed by transcript evidence
NP_001256524.1
  • Confirmed by transcript evidence
NP_001256525.1
  • Confirmed by transcript evidence
NP_001256526.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    13557104..13559922
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001269594.3 → NP_001256523.1  Caveolin-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256523.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    E1B6T3, E1B6T4, G3MU34, Q18879
    Conserved Domains (1) summary
    pfam01146
    Location:209 → 335
    Caveolin; Caveolin

  2. NM_001269595.3 → NP_001256524.1  Caveolin-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256524.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q18879
    Conserved Domains (1) summary
    pfam01146
    Location:139 → 265
    Caveolin; Caveolin

  3. NM_001269596.3 → NP_001256525.1  Caveolin-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256525.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q18879
    Conserved Domains (1) summary
    pfam01146
    Location:177 → 303
    Caveolin; Caveolin

  4. NM_001269597.3 → NP_001256526.1  Caveolin-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256526.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q18879
    Conserved Domains (1) summary
    pfam01146
    Location:18 → 144
    Caveolin; Caveolin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q18879.3

Gene LinkOut

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