U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

fmo-4 Flavin-containing monooxygenase [ Caenorhabditis elegans ]

Gene ID: 179845, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
fmo-4
Official Full Name
Flavin-containing monooxygenase
Primary source
WormBase:WBGene00001479
Locus tag
CELE_F53F4.5
See related
AllianceGenome:WB:WBGene00001479
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable monooxygenase activity. Predicted to be involved in lipid metabolic process. Predicted to be located in endoplasmic reticulum membrane. Is expressed in excretory system; hypodermis; intestine; nervous system; and reproductive system. Human ortholog(s) of this gene implicated in hypertension; inherited metabolic disorder; and trimethylaminuria. Orthologous to several human genes including FMO2 (flavin containing dimethylaniline monoxygenase 2); FMO3 (flavin containing dimethylaniline monoxygenase 3); and FMO4 (flavin containing dimethylaniline monoxygenase 4). [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See fmo-4 in Genome Data Viewer
Location:
chromosome: V
Exon count:
7
Sequence:
Chromosome: V; NC_003283.11 (13603276..13606701, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene MARVEL domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Minor capsid protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. C. elegans flavin-containing monooxygenase-4 is essential for osmoregulation in hypotonic stress. Hirani N, et al. Biol Open, 2016 May 15. PMID 27010030, Free PMC Article
  2. The fmo genes of Caenorhabditis elegans and C. briggsae: characterisation, gene expression and comparative genomic analysis. Petalcorin MI, et al. Gene, 2005 Feb 14. PMID 15716098
  3. The PH/MyTH4/FERM molecule MAX-1 inhibits UNC-5 activity in the regulation of VD growth cone protrusion in Caenorhabditis elegans. Mahadik SS, et al. Genetics, 2022 May 5. PMID 35348689, Free PMC Article
  4. Flavin monooxygenases regulate Caenorhabditis elegans axon guidance and growth cone protrusion with UNC-6/Netrin signaling and Rac GTPases. Gujar MR, et al. PLoS Genet, 2017 Aug. PMID 28859089, Free PMC Article
  5. Roles of the HIF-1 hypoxia-inducible factor during hypoxia response in Caenorhabditis elegans. Shen C, et al. J Biol Chem, 2005 May 27. PMID 15781453

See all (8) citations in PubMed

GeneRIFs: Gene References Into Functions

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables N,N-dimethylaniline monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables NAD(P)H oxidase H2O2-forming activity IEA
Inferred from Electronic Annotation
more info
  
enables NADP binding IEA
Inferred from Electronic Annotation
more info
  
enables flavin adenine dinucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables hypotaurine monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
enables monooxygenase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables monooxygenase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Flavin-containing monooxygenase
NP_001256532.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    13603276..13606701 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001269603.2 → NP_001256532.1  Flavin-containing monooxygenase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256532.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EDG8
    Conserved Domains (2) summary
    pfam00743
    Location:2 → 488
    FMO-like; Flavin-binding monooxygenase-like
    cl21454
    Location:4 → 209
    NADB_Rossmann; Rossmann-fold NAD(P)(+)-binding proteins

RNA

  1. NR_069899.1 RNA Sequence

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools
Miscellaneous