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hlh-34 Helix-loop-helix 34 [ Caenorhabditis elegans ]

Gene ID: 179860, updated on 2-Nov-2024

Summary

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Official Symbol
hlh-34
Official Full Name
Helix-loop-helix 34
Primary source
WormBase:WBGene00011327
Locus tag
CELE_T01D3.2
See related
AllianceGenome:WB:WBGene00011327
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable DNA binding activity. Involved in several processes, including nematode pharyngeal pumping; neuron fate specification; and serotonin receptor signaling pathway. Predicted to be located in nucleus. Is expressed in several structures, including ABalapaaaa; ABalapaaap; ABalappapa; ABalappapp; and head neurons. Human ortholog(s) of this gene implicated in several diseases, including artery disease (multiple); lung non-small cell carcinoma; obesity; polycythemia (multiple); and type 2 diabetes mellitus. Orthologous to several human genes including SIM1 (SIM bHLH transcription factor 1); SIM2 (SIM bHLH transcription factor 2); and HIF3A (hypoxia inducible factor 3 subunit alpha). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hlh-34 in Genome Data Viewer
Location:
chromosome: V
Exon count:
4
Sequence:
Chromosome: V; NC_003283.11 (13705967..13707395, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene EGF-like domain-containing protein Neighboring gene ncRNA Neighboring gene TIL domain-containing protein;Thyroglobulin type-1 domain-containing protein Neighboring gene ncRNA Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene Zinc transporter ZIP9

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. The bHLH-PAS gene hlh-34 is expressed in the AVH, not AVJ interneurons. Cook SJ, et al. MicroPubl Biol, 2021. PMID 34604715, Free PMC Article
  2. AMP-activated kinase links serotonergic signaling to glutamate release for regulation of feeding behavior in C. elegans. Cunningham KA, et al. Cell Metab, 2012 Jul 3. PMID 22768843, Free PMC Article
  3. The Prop1-like homeobox gene unc-42 specifies the identity of synaptically connected neurons. Berghoff EG, et al. Elife, 2021 Jun 24. PMID 34165428, Free PMC Article
  4. ngn-1/neurogenin Activates Transcription of Multiple Terminal Selector Transcription Factors in the Caenorhabditis elegans Nervous System. Christensen EL, et al. G3 (Bethesda), 2020 Jun 1. PMID 32273286, Free PMC Article
  5. Kynurenic acid is a nutritional cue that enables behavioral plasticity. Lemieux GA, et al. Cell, 2015 Jan 15. PMID 25594177, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables DNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cell differentiation IEA
Inferred from Electronic Annotation
more info
  
involved_in nematode pharyngeal pumping IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in nervous system development IEA
Inferred from Electronic Annotation
more info
  
involved_in neuron fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-templated transcription IEA
Inferred from Electronic Annotation
more info
  
involved_in serotonin receptor signaling pathway IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Helix-loop-helix 34
NP_506391.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    13705967..13707395 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_073990.5 → NP_506391.2  Helix-loop-helix 34 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506391.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    P90953, Q963J3
    Conserved Domains (2) summary
    cd00083
    Location:6 → 67
    HLH; Helix-loop-helix domain, found in specific DNA- binding proteins that act as transcription factors; 60-100 amino acids long. A DNA-binding basic region is followed by two alpha-helices separated by a variable loop region; HLH forms homo- and heterodimers, ...
    cd00130
    Location:93 → 145
    PAS; PAS domain; PAS motifs appear in archaea, eubacteria and eukarya. Probably the most surprising identification of a PAS domain was that in EAG-like K+-channels. PAS domains have been found to bind ligands, and to act as sensors for light and oxygen in ...
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P90953.3

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