sel-10 F-box/WD repeat-containing protein sel-10 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: sel-10
Official Full Name: F-box/WD repeat-containing protein sel-10
Primary source: WormBase:WBGene00004767
Locus tag: CELE_F55B12.3
See related: AllianceGenome:WB:WBGene00004767
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables protein homodimerization activity and protein kinase binding activity. Involved in several processes, including negative regulation of Notch signaling pathway; negative regulation of centrosome duplication; and regulation of vulval development. Located in axon and cytoplasm. Is expressed in body wall musculature; gonad; intestine; neurons; and pharynx. Human ortholog(s) of this gene implicated in developmental delay, hypotonia, and impaired language. Orthologous to human FBXW7 (F-box and WD repeat domain containing 7). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See sel-10 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 11

Sequence:: Chromosome: V; NC_003283.11 (13819361..13822980)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Synaptic Protein Degradation Controls Sexually Dimorphic Circuits through Regulation of DCC/UNC-40.
Title: Synaptic Protein Degradation Controls Sexually Dimorphic Circuits through Regulation of DCC/UNC-40.
Negative feedback by conserved kinases patterns the degradation of Caenorhabditis elegans Raf in vulval fate patterning.
Title: Negative feedback by conserved kinases patterns the degradation of Caenorhabditiselegans Raf in vulval fate patterning.
Data show that a second F-box protein, SEL-10, also contributes to ZYG-1 regulation. Co-depletion of LIN-23 and SEL-10 suggests these proteins function cooperatively.
Title: The C. elegans F-box proteins LIN-23 and SEL-10 antagonize centrosome duplication by regulating ZYG-1 levels.
Combined analysis of the SAO-1-SEL-10 protein interaction and comparisons of sao-1 and sel-10 genetic interactions suggest a possible role for SAO-1 as an accessory protein that participates with SEL-10 in downregulation of Notch signaling.
Title: Notch signaling is antagonized by SAO-1, a novel GYF-domain protein that interacts with the E3 ubiquitin ligase SEL-10 in Caenorhabditis elegans.
study found stereotyped developmental elimination of synapses in the motor neuron (HSNL) was mediated by a Skp1-cullin-F-box (SCF) complex composed of SKR-1 & SEL-10; SYG-1 bound to SKR-1 & inhibited assembly of the SCF complex, protecting nearby synapses
Title: Spatial regulation of an E3 ubiquitin ligase directs selective synapse elimination.
Results suggest that SEL-10-mediated proteolysis of FEM-1 and FEM-3 is required for normal hermaphrodite development.
Title: The Caenorhabditis elegans F-box protein SEL-10 promotes female development and may target FEM-1 and FEM-3 for degradation by the proteasome.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

F55B12.3 (e-PCR)
- UniSTS:305638

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein homodimerization activity	IPI Inferred from Physical Interaction more info	PubMed
enables protein kinase binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in cell differentiation	IEA Inferred from Electronic Annotation more info
involved_in female sex differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in negative regulation of centrosome duplication	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of Notch signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of protein stability	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of vulval development	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sex differentiation	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in axon	IDA Inferred from Direct Assay more info	PubMed
located_in axon	IEA Inferred from Electronic Annotation more info
located_in cell projection	IEA Inferred from Electronic Annotation more info
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: F-box/WD repeat-containing protein sel-10

NP_001023975.1

Confirmed by transcript evidence

NP_506421.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

13819361..13822980

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_074020.8 → NP_506421.1 F-box/WD repeat-containing protein sel-10 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_506421.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O44083, Q93794, Q95ZT0

Conserved Domains (5) summary

COG2319
Location:243 → 532

WD40; WD40 repeat [General function prediction only]

cd00200
Location:248 → 530

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam12937
Location:124 → 167

F-box-like; F-box-like

sd00039
Location:259 → 294

7WD40; WD40 repeat [structural motif]

cl02567
Location:495 → 572

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...
NM_001028804.5 → NP_001023975.1 F-box/WD repeat-containing protein sel-10 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001023975.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q93794

Conserved Domains (5) summary

COG2319
Location:241 → 530

WD40; WD40 repeat [General function prediction only]

cd00200
Location:246 → 528

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...

pfam12937
Location:122 → 165

F-box-like; F-box-like

sd00039
Location:257 → 292

7WD40; WD40 repeat [structural motif]

cl02567
Location:493 → 570

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...