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sptl-3 Serine palmitoyltransferase 3 [ Caenorhabditis elegans ]

Gene ID: 179884, updated on 2-Nov-2024

Summary

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Official Symbol
sptl-3
Official Full Name
Serine palmitoyltransferase 3
Primary source
WormBase:WBGene00011932
Locus tag
CELE_T22G5.5
See related
AllianceGenome:WB:WBGene00011932
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable serine C-palmitoyltransferase activity. Predicted to be involved in ceramide biosynthetic process and sphingosine biosynthetic process. Predicted to be part of serine palmitoyltransferase complex. Human ortholog(s) of this gene implicated in hereditary sensory and autonomic neuropathy type 1C. Orthologous to human SPTLC2 (serine palmitoyltransferase long chain base subunit 2) and SPTLC3 (serine palmitoyltransferase long chain base subunit 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See sptl-3 in Genome Data Viewer
Location:
chromosome: V
Exon count:
11
Sequence:
Chromosome: V; NC_003283.11 (13893325..13896415)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Fatty acid-binding protein homolog 8 Neighboring gene CYtochrome P450 family Neighboring gene Nose resistant-to-fluoxetine protein N-terminal domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Probiotic Bacillus subtilis Protects against α-Synuclein Aggregation in C. elegans. Goya ME, et al. Cell Rep, 2020 Jan 14. PMID 31940482, Free PMC Article
  2. Apicobasal domain identities of expanding tubular membranes depend on glycosphingolipid biosynthesis. Zhang H, et al. Nat Cell Biol, 2011 Sep 18. PMID 21926990, Free PMC Article
  3. Ceramide biogenesis is required for radiation-induced apoptosis in the germ line of C. elegans. Deng X, et al. Science, 2008 Oct 3. PMID 18832646, Free PMC Article
  4. SGPL1 stimulates VPS39 recruitment to the mitochondria in MICU1 deficient cells. Jackson J, et al. Mol Metab, 2022 Jul. PMID 35452878, Free PMC Article
  5. Antagonistic fungal enterotoxins intersect at multiple levels with host innate immune defences. Zhang X, et al. PLoS Genet, 2021 Jun. PMID 34166401, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
enables serine C-palmitoyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine C-palmitoyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in ceramide biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in sphingolipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in sphingosine biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
part_of serine palmitoyltransferase complex IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Serine palmitoyltransferase 3
NP_001256547.1
  • Partially confirmed by transcript evidence
NP_001256548.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    13893325..13896415
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001269618.3 → NP_001256547.1  Serine palmitoyltransferase 3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256547.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XVI6
    Conserved Domains (2) summary
    PLN02483
    Location:87 → 514
    PLN02483; serine palmitoyltransferase
    COG0156
    Location:123 → 507
    BioF; 7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]

  2. NM_001269619.3 → NP_001256548.1  Serine palmitoyltransferase 3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256548.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    H9G307, Q9XVI6
    Conserved Domains (2) summary
    PLN02483
    Location:78 → 505
    PLN02483; serine palmitoyltransferase
    COG0156
    Location:114 → 498
    BioF; 7-keto-8-aminopelargonate synthetase or related enzyme [Coenzyme transport and metabolism]
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XVI6.2

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