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cest-1.2 Carboxylic ester hydrolase [ Caenorhabditis elegans ]

Gene ID: 179914, updated on 2-Nov-2024

Summary

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Official Symbol
cest-1.2
Official Full Name
Carboxylic ester hydrolase
Primary source
WormBase:WBGene00011364
Locus tag
CELE_T02B5.3
See related
AllianceGenome:WB:WBGene00011364
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable carboxylic ester hydrolase activity. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in colorectal cancer and gastrointestinal system cancer. Orthologous to human CES1 (carboxylesterase 1) and CES4A (carboxylesterase 4A). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cest-1.2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
11
Sequence:
Chromosome: V; NC_003283.11 (14157663..14160862, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene Transmembrane domain-containing protein Neighboring gene ncRNA Neighboring gene Serpentine receptor class delta-26 Neighboring gene Carboxylic ester hydrolase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Combinatorial Assembly of Modular Glucosides via Carboxylesterases Regulates C. elegans Starvation Survival. Wrobel CJJ, et al. J Am Chem Soc, 2021 Sep 15. PMID 34460264, Free PMC Article
  2. Oligonucleotide Catabolism-Derived Gluconucleosides in Caenorhabditis elegans. Curtis BJ, et al. J Am Chem Soc, 2023 May 31. PMID 37192367, Free PMC Article
  3. The Caenorhabditis elegans heterochronic regulator LIN-14 is a novel transcription factor that controls the developmental timing of transcription from the insulin/insulin-like growth factor gene ins-33 by direct DNA binding. Hristova M, et al. Mol Cell Biol, 2005 Dec. PMID 16314527, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables carboxylic ester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Carboxylic ester hydrolase
NP_506504.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    14157663..14160862 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_074103.7 → NP_506504.2  Carboxylic ester hydrolase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506504.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    P92016
    Conserved Domains (2) summary
    COG0657
    Location:125 → 250
    Aes; Acetyl esterase/lipase [Lipid transport and metabolism]
    pfam00135
    Location:21 → 536
    COesterase; Carboxylesterase family
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

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