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ent-3 Equilibrative Nucleoside Transporter [ Caenorhabditis elegans ]

Gene ID: 179926, updated on 2-Nov-2024

Summary

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Official Symbol
ent-3
Official Full Name
Equilibrative Nucleoside Transporter
Primary source
WormBase:WBGene00010510
Locus tag
CELE_K02E11.1
See related
AllianceGenome:WB:WBGene00010510
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable nucleoside transmembrane transporter activity. Predicted to be involved in nucleoside transmembrane transport. Predicted to be located in membrane. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in histiocytosis-lymphadenopathy plus syndrome. Orthologous to human SLC29A2 (solute carrier family 29 member 2) and SLC29A3 (solute carrier family 29 member 3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See ent-3 in Genome Data Viewer
Location:
chromosome: V
Exon count:
15
Sequence:
Chromosome: V; NC_003283.11 (14232281..14236042, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene tRNA-Gln Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Functional redundancy of two nucleoside transporters of the ENT family (CeENT1, CeENT2) required for development of Caenorhabditis elegans. Appleford PJ, et al. Mol Membr Biol, 2004 Jul-Aug. PMID 15371014
  2. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  3. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  4. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables nucleoside transmembrane transporter activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables nucleoside transmembrane transporter activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in nucleoside transmembrane transport IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleoside transport IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
Equilibrative Nucleoside Transporter
NP_506521.2
  • Product from WormBase gene class ent;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    14232281..14236042 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_074120.5 → NP_506521.2  Equilibrative Nucleoside Transporter [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506521.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q21145
    Conserved Domains (2) summary
    pfam01733
    Location:434 → 723
    Nucleoside_tran; Nucleoside transporter
    cl21678
    Location:121 → 234
    ChlI; Subunit ChlI of Mg-chelatase
Nucleotide Protein
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