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dhs-22 DeHydrogenases, Short chain [ Caenorhabditis elegans ]

Gene ID: 179940, updated on 2-Nov-2024

Summary

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Official Symbol
dhs-22
Official Full Name
DeHydrogenases, Short chain
Primary source
WormBase:WBGene00000985
Locus tag
CELE_C15H11.4
See related
AllianceGenome:WB:WBGene00000985
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable oxidoreductase activity. Predicted to be located in membrane. Human ortholog(s) of this gene implicated in Leber congenital amaurosis 13 and Leber hereditary optic neuropathy. Orthologous to several human genes including DHRS13 (dehydrogenase/reductase 13); RDH11 (retinol dehydrogenase 11); and RDH12 (retinol dehydrogenase 12). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dhs-22 in Genome Data Viewer
Location:
chromosome: V
Exon count:
4
Sequence:
Chromosome: V; NC_003283.11 (14420071..14421440, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene Nuclear RNA export factor 1 Neighboring gene Cytochrome b-c1 complex subunit 10;Essential MCU regulator, mitochondrial Neighboring gene Nuclear RNA export factor 2 Neighboring gene SET domain-containing protein Neighboring gene Proteasome subunit alpha type-6 Neighboring gene DNA-directed RNA polymerase subunit

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Alternative chaperone machinery may compensate for calreticulin/calnexin deficiency in Caenorhabditis elegans. Lee W, et al. Proteomics, 2006 Feb. PMID 16404716
  2. Comparative genomics and functional study of lipid metabolic genes in Caenorhabditis elegans. Zhang Y, et al. BMC Genomics, 2013 Mar 12. PMID 23496871, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables oxidoreductase activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
DeHydrogenases, Short chain
NP_506570.1
  • Product from WormBase gene class dhs;
    Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    14420071..14421440 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_074169.8 → NP_506570.1  DeHydrogenases, Short chain [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506570.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XVS9
    Conserved Domains (2) summary
    cd05327
    Location:46 → 322
    retinol-DH_like_SDR_c_like; retinol dehydrogenase (retinol-DH), Light dependent Protochlorophyllide (Pchlide) OxidoReductase (LPOR) and related proteins, classical (c) SDRs
    PRK06197
    Location:45 → 330
    PRK06197; short chain dehydrogenase; Provisional
Nucleotide Protein
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