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coh-3 Rad21/Rec8-like protein C-terminal eukaryotic domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 179949, updated on 2-Nov-2024

Summary

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Official Symbol
coh-3
Official Full Name
Rad21/Rec8-like protein C-terminal eukaryotic domain-containing protein
Primary source
WormBase:WBGene00000592
Locus tag
CELE_F08H9.1
See related
AllianceGenome:WB:WBGene00000592
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Involved in meiotic sister chromatid cohesion. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See coh-3 in Genome Data Viewer
Location:
chromosome: V
Exon count:
13
Sequence:
Chromosome: V; NC_003283.11 (14457422..14460141)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Kinesin-like protein Neighboring gene SPerm CHromatin enriched Neighboring gene SHSP domain-containing protein Neighboring gene ncRNA Neighboring gene ncRNA

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Superresolution microscopy reveals the three-dimensional organization of meiotic chromosome axes in intact Caenorhabditis elegans tissue. Köhler S, et al. Proc Natl Acad Sci U S A, 2017 Jun 13. PMID 28559338, Free PMC Article
  2. Divergent kleisin subunits of cohesin specify mechanisms to tether and release meiotic chromosomes. Severson AF, et al. Elife, 2014 Aug 29. PMID 25171895, Free PMC Article
  3. Cohesin-interacting protein WAPL-1 regulates meiotic chromosome structure and cohesion by antagonizing specific cohesin complexes. Crawley O, et al. Elife, 2016 Feb 4. PMID 26841696, Free PMC Article
  4. The kleisin subunit controls the function of C. elegans meiotic cohesins by determining the mode of DNA binding and differential regulation by SCC-2 and WAPL-1. Castellano-Pozo M, et al. Elife, 2023 Aug 31. PMID 37650378, Free PMC Article
  5. Cohesin is required for meiotic spindle assembly independent of its role in cohesion in C. elegans. McNally KP, et al. PLoS Genet, 2022 Oct. PMID 36279281, Free PMC Article

See all (17) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. WAPL-1-sensitive COH-3/4 complexes modulate higher-order chromosome structure, while WAPL-1-refractory REC-8 complexes provide stable cohesion.
    Title: Cohesin-interacting protein WAPL-1 regulates meiotic chromosome structure and cohesion by antagonizing specific cohesin complexes.
  2. COH-3/4 cohesin becomes cohesive through a replication-independent mechanism initiated by the DNA double-stranded breaks that induce crossover recombination.
    Title: Divergent kleisin subunits of cohesin specify mechanisms to tether and release meiotic chromosomes.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in meiotic sister chromatid cohesion IMP
Inferred from Mutant Phenotype
more info
 PubMed 

General protein information

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Preferred Names
Rad21/Rec8-like protein C-terminal eukaryotic domain-containing protein
NP_506583.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    14457422..14460141
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_074182.3 → NP_506583.2  Rad21/Rec8-like protein C-terminal eukaryotic domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506583.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q19232
    Conserved Domains (1) summary
    pfam04824
    Location:543 → 595
    Rad21_Rec8; Conserved region of Rad21 / Rec8 like protein
Nucleotide Protein
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