gar-3 Muscarinic acetylcholine receptor gar-3 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: gar-3
Official Full Name: Muscarinic acetylcholine receptor gar-3
Primary source: WormBase:WBGene00001519
Locus tag: CELE_Y40H4A.1
See related: AllianceGenome:WB:WBGene00001519
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables G protein-coupled acetylcholine receptor activity. Involved in several processes, including G protein-coupled acetylcholine receptor signaling pathway; positive regulation of acetylcholine secretion, neurotransmission; and positive regulation of protein localization to synapse. Located in plasma membrane. Is expressed in body wall musculature; linker cell; neurons; non-striated muscle; and somatic nervous system. Human ortholog(s) of this gene implicated in several diseases, including Chagas disease; autoimmune disease of the nervous system (multiple); heroin dependence; lung disease (multiple); and prune belly syndrome. Orthologous to several human genes including CHRM1 (cholinergic receptor muscarinic 1); CHRM3 (cholinergic receptor muscarinic 3); and CHRM5 (cholinergic receptor muscarinic 5). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See gar-3 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 12

Sequence:: Chromosome: V; NC_003283.11 (14564819..14579719, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Cross talk between the nAChR EAT-2 and the mAChR GAR-3 affects peristaltic muscle contractions in the isthmus of the C. elegans pharynx.
Title: Cross Talk with the GAR-3 Receptor Contributes to Feeding Defects in Caenorhabditis elegans eat-2 Mutants.
GAR-3-mediated ERK1/2 activation occurs through interaction with the i3 loop of GAR-3.
Title: The C. elegans VIG-1 and FRM-1 modulate carbachol-stimulated ERK1/2 activation in chinese hamster ovary cells expressing the muscarinic acetylcholine receptor GAR-3.
In GAR-3 mutants that are no longer asymmetrically localized, synaptic transmission at neuromuscular junctions is impaired.
Title: Extrasynaptic muscarinic acetylcholine receptors on neuronal cell bodies regulate presynaptic function in Caenorhabditis elegans.
Regulates multiple calcium-dependent processes in the C. elegans pharyngeal muscle.
Title: The GAR-3 muscarinic receptor cooperates with calcium signals to regulate muscle contraction in the Caenorhabditis elegans pharynx.
The GAR-3(mAChR)/G alpha(q) pathway sensitizes the spicule neurons and muscles before and during mating so that the male can respond to hermaphrodite vulva efficiently.
Title: G alpha(q)-coupled muscarinic acetylcholine receptors enhance nicotinic acetylcholine receptor signaling in Caenorhabditis elegans mating behavior.
alternative splicing plays an important role in promoting molecular diversity of GAR-3 in C. elegans
Title: Alternative splicing of the muscarinic acetylcholine receptor GAR-3 in Caenorhabditis elegans.

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Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y40H4A.1 (e-PCR)
- UniSTS:318784

C53A5.12 (e-PCR)
- UniSTS:319162

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables G protein-coupled acetylcholine receptor activity	IBA Inferred from Biological aspect of Ancestor more info
enables G protein-coupled acetylcholine receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled acetylcholine receptor activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables G protein-coupled amine receptor activity	IEA Inferred from Electronic Annotation more info
enables G protein-coupled receptor activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in G protein-coupled acetylcholine receptor signaling pathway	IGI Inferred from Genetic Interaction more info	PubMed
involved_in G protein-coupled acetylcholine receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G protein-coupled receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in G protein-coupled receptor signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in G protein-coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger	IBA Inferred from Biological aspect of Ancestor more info
involved_in G protein-coupled serotonin receptor signaling pathway	IEA Inferred from Electronic Annotation more info
involved_in action potential	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in adenylate cyclase-inhibiting G protein-coupled acetylcholine receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cellular response to nitrogen compound	IEA Inferred from Electronic Annotation more info
involved_in chemical synaptic transmission	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of acetylcholine secretion, neurotransmission	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of protein localization to synapse	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of nematode pharyngeal pumping	IGI Inferred from Genetic Interaction more info	PubMed
involved_in regulation of nematode pharyngeal pumping	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to xenobiotic stimulus	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in dendrite	IBA Inferred from Biological aspect of Ancestor more info
located_in membrane	IEA Inferred from Electronic Annotation more info
is_active_in plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in plasma membrane	IDA Inferred from Direct Assay more info	PubMed
located_in plasma membrane	IEA Inferred from Electronic Annotation more info
is_active_in synapse	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Muscarinic acetylcholine receptor gar-3

NP_001024235.1

Confirmed by transcript evidence

NP_001024236.1

Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

14564819..14579719 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001029064.4 → NP_001024235.1 Muscarinic acetylcholine receptor gar-3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024235.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9U7D5

Conserved Domains (2) summary

pfam00001
Location:82 → 286

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:77 → 202

7tm_4; Olfactory receptor
NM_001029065.5 → NP_001024236.1 Muscarinic acetylcholine receptor gar-3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001024236.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q7JKV1, Q9U7D5, Q9XW31

Conserved Domains (2) summary

pfam00001
Location:82 → 263

7tm_1; 7 transmembrane receptor (rhodopsin family)

cl21561
Location:77 → 202

7tm_4; Olfactory receptor