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fib-1 rRNA 2'-O-methyltransferase fibrillarin [ Caenorhabditis elegans ]

Gene ID: 179999, updated on 2-Nov-2024

Summary

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Official Symbol
fib-1
Official Full Name
rRNA 2'-O-methyltransferase fibrillarin
Primary source
WormBase:WBGene00001423
Locus tag
CELE_T01C3.7
See related
AllianceGenome:WB:WBGene00001423
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable RNA binding activity; histone H2AQ104 methyltransferase activity; and rRNA methyltransferase activity. Involved in nucleologenesis and positive regulation of translation. Located in nucleolus and nucleoplasm. Orthologous to several human genes including FBL (fibrillarin). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See fib-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
4
Sequence:
Chromosome: V; NC_003283.11 (15000653..15001969, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Spore coat protein;Transmembrane protein Neighboring gene Small ribosomal subunit protein uS9 Neighboring gene MUTator Neighboring gene Protein hrde-2 Neighboring gene Ionotropic glutamate receptor C-terminal domain-containing protein;PBPe domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Nucleolar fibrillarin is an evolutionarily conserved regulator of bacterial pathogen resistance. Tiku V, et al. Nat Commun, 2018 Sep 6. PMID 30190478, Free PMC Article
  2. The Caenorhabditis elegans orthologue of the human gene responsible for spinal muscular atrophy is a maternal product critical for germline maturation and embryonic viability. Miguel-Aliaga I, et al. Hum Mol Genet, 1999 Nov. PMID 10545592
  3. RBD-1, a nucleolar RNA-binding protein, is essential for Caenorhabditis elegans early development through 18S ribosomal RNA processing. Saijou E, et al. Nucleic Acids Res, 2004. PMID 14872060, Free PMC Article
  4. The nucleolus of Caenorhabditis elegans. Lee LW, et al. J Biomed Biotechnol, 2012. PMID 22577294, Free PMC Article
  5. New insights into polycistronic transcripts in eukaryotes. Pi H, et al. Chang Gung Med J, 2009 Sep-Oct. PMID 19840506

See all (41) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables RNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA binding IEA
Inferred from Electronic Annotation
more info
  
enables histone H2AQ104 methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables methyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables rRNA methyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in box C/D sno(s)RNA 3'-end processing IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in chromatin remodeling IEA
Inferred from Electronic Annotation
more info
  
involved_in methylation IEA
Inferred from Electronic Annotation
more info
  
involved_in nucleologenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of translation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in rRNA methylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in rRNA processing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in Cajal body IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of box C/D methylation guide snoRNP complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleolus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleolus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleolus IEA
Inferred from Electronic Annotation
more info
  
located_in nucleoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  
part_of ribonucleoprotein complex IEA
Inferred from Electronic Annotation
more info
  
part_of small-subunit processome IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
rRNA 2'-O-methyltransferase fibrillarin
NP_506691.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    15000653..15001969 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_074290.7 → NP_506691.1  rRNA 2'-O-methyltransferase fibrillarin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506691.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22053
    Conserved Domains (1) summary
    PTZ00146
    Location:115 → 351
    PTZ00146; fibrillarin; Provisional
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q22053.1

Gene LinkOut

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