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hrde-2 Protein hrde-2 [ Caenorhabditis elegans ]

Gene ID: 180001, updated on 2-Nov-2024

Summary

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Official Symbol
hrde-2
Official Full Name
Protein hrde-2
Primary source
WormBase:WBGene00011324
Locus tag
CELE_T01C3.9
See related
AllianceGenome:WB:WBGene00011324
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to be involved in regulatory ncRNA-mediated gene silencing. Predicted to be located in nucleus. Is expressed in Z2; Z3; germ line; sperm; and in male. [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See hrde-2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
4
Sequence:
Chromosome: V; NC_003283.11 (15005100..15006400)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene rRNA 2'-O-methyltransferase fibrillarin Neighboring gene MUTator Neighboring gene Ionotropic glutamate receptor C-terminal domain-containing protein;PBPe domain-containing protein Neighboring gene Oxysterol binding protein;Oxysterol-binding protein Neighboring gene ncRNA Neighboring gene tRNA-Val Neighboring gene SPX domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A Family of Argonaute-Interacting Proteins Gates Nuclear RNAi. Lewis A, et al. Mol Cell, 2020 Jun 4. PMID 32348780, Free PMC Article
  2. The RNAi Inheritance Machinery of Caenorhabditis elegans. Spracklin G, et al. Genetics, 2017 Jul. PMID 28533440, Free PMC Article
  3. The nuclear Argonaute HRDE-1 directs target gene re-localization and shuttles to nuage to promote small RNA-mediated inherited silencing. Ding YH, et al. Cell Rep, 2023 May 30. PMID 37083324, Free PMC Article
  4. HRDE-2 drives small RNA specificity for the nuclear Argonaute protein HRDE-1. Chen S, et al. Nat Commun, 2024 Feb 1. PMID 38302462, Free PMC Article
  5. Empirically controlled mapping of the Caenorhabditis elegans protein-protein interactome network. Simonis N, et al. Nat Methods, 2009 Jan. PMID 19123269, Free PMC Article

See all (6) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. HRDE-2 drives small RNA specificity for the nuclear Argonaute protein HRDE-1.
    Title: HRDE-2 drives small RNA specificity for the nuclear Argonaute protein HRDE-1.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Process Evidence Code Pubs
involved_in regulatory ncRNA-mediated gene silencing IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Protein hrde-2
NP_506693.1
  • Partially confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    15005100..15006400
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_074292.6 → NP_506693.1  Protein hrde-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506693.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q22058
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q22058.1

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