U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

plc-2 Phosphoinositide phospholipase C [ Caenorhabditis elegans ]

Gene ID: 180029, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
plc-2
Official Full Name
Phosphoinositide phospholipase C
Primary source
WormBase:WBGene00004037
Locus tag
CELE_Y75B12B.6
See related
AllianceGenome:WB:WBGene00004037
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable phosphatidylinositol phospholipase C activity. Predicted to be involved in phosphatidylinositol metabolic process; phosphatidylinositol-mediated signaling; and release of sequestered calcium ion into cytosol. [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See plc-2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
14
Sequence:
Chromosome: V; NC_003283.11 (15192572..15197624)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene ncRNA Neighboring gene Secreted protein Neighboring gene Secreted protein Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene G_PROTEIN_RECEP_F1_2 domain-containing protein

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. Phospholipase C-epsilon regulates epidermal morphogenesis in Caenorhabditis elegans. Vázquez-Manrique RP, et al. PLoS Genet, 2008 Mar 28. PMID 18369461, Free PMC Article
  2. Inositol 1,4,5-trisphosphate signaling regulates mating behavior in Caenorhabditis elegans males. Gower NJ, et al. Mol Biol Cell, 2005 Sep. PMID 15958491, Free PMC Article
  3. IP3 signalling regulates exogenous RNAi in Caenorhabditis elegans. Nagy AI, et al. EMBO Rep, 2015 Mar. PMID 25608529, Free PMC Article
  4. Oscillatory Ca2+ signaling in the isolated Caenorhabditis elegans intestine: role of the inositol-1,4,5-trisphosphate receptor and phospholipases C beta and gamma. Espelt MV, et al. J Gen Physiol, 2005 Oct. PMID 16186564, Free PMC Article
  5. Inositol 1,4,5-trisphosphate signaling regulates rhythmic contractile activity of myoepithelial sheath cells in Caenorhabditis elegans. Yin X, et al. Mol Biol Cell, 2004 Aug. PMID 15194811, Free PMC Article

See all (10) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphatidylinositol phospholipase C activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phosphatidylinositol phospholipase C activity IEA
Inferred from Electronic Annotation
more info
  
enables phosphoric diester hydrolase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in intracellular signal transduction IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid catabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in lipid metabolic process IEA
Inferred from Electronic Annotation
more info
  
involved_in phosphatidylinositol metabolic process IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phosphatidylinositol-mediated signaling IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in release of sequestered calcium ion into cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in signal transduction IEA
Inferred from Electronic Annotation
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Phosphoinositide phospholipase C
NP_506752.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    15192572..15197624
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_074351.6 → NP_506752.1  Phosphoinositide phospholipase C [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506752.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XWB7
    Conserved Domains (3) summary
    cd00275
    Location:670 → 807
    C2_PLC_like; C2 domain present in Phosphoinositide-specific phospholipases C (PLC)
    cd08558
    Location:306 → 638
    PI-PLCc_eukaryota; Catalytic domain of eukaryotic phosphoinositide-specific phospholipase C and similar proteins
    cl17171
    Location:16 → 134
    PH-like; Pleckstrin homology-like domain
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools