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cyb-3 G2/mitotic-specific cyclin-B3 [ Caenorhabditis elegans ]

Gene ID: 180040, updated on 2-Nov-2024

Summary

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Official Symbol
cyb-3
Official Full Name
G2/mitotic-specific cyclin-B3
Primary source
WormBase:WBGene00000868
Locus tag
CELE_T06E6.2
See related
AllianceGenome:WB:WBGene00000868
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables cyclin-dependent protein serine/threonine kinase regulator activity. Involved in several processes, including chromosome organization; positive regulation of mitotic metaphase/anaphase transition; and pronuclear migration. Acts upstream of or within nematode male tail tip morphogenesis. Located in cytoplasm and nucleus. Is expressed in several structures, including AB; EMS; Psub1; germ line; and gonad. Orthologous to human CCNB3 (cyclin B3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cyb-3 in Genome Data Viewer
Location:
chromosome: V
Exon count:
5
Sequence:
Chromosome: V; NC_003283.11 (15395696..15397351)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class H Neighboring gene WD repeat-containing protein 74 Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene F-box domain-containing protein

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Cyclin B3 is a dominant fast-acting cyclin that drives rapid early embryonic mitoses. Lara-Gonzalez P, et al. J Cell Biol, 2024 Nov 4. PMID 39105756,
  2. Cyclin CYB-3 controls both S-phase and mitosis and is asymmetrically distributed in the early C. elegans embryo. Michael WM. Development, 2016 Sep 1. PMID 27578178, Free PMC Article
  3. Duplication of cyb-3 (cyclin B3) suppresses sterility in the absence of mdf-1/MAD1 spindle assembly checkpoint component in Caenorhabditis elegans. Tarailo-Graovac M, et al. Cell Cycle, 2010 Dec 15. PMID 21131781
  4. Asymmetric distribution of cyb-3 in 4-cell stage embryos. Michael WM. MicroPubl Biol, 2017 Mar 21. PMID 32550359, Free PMC Article
  5. Proper cyclin B3 dosage is important for precision of metaphase-to-anaphase onset timing in Caenorhabditis elegans. Tarailo-Graovac M, et al. G3 (Bethesda), 2012 Aug. PMID 22908035, Free PMC Article

See all (38) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Cyclin B3 is a dominant fast-acting cyclin that drives rapid early embryonic mitoses.
    Title: Cyclin B3 is a dominant fast-acting cyclin that drives rapid early embryonic mitoses.
  2. The findings highlight the importance of the CYB-3 B3-type cyclin in cell cycle regulation in the early embryo and suggest that CYB-3 asymmetry helps establish the well-documented cell cycle asynchrony that occurs during cell division within the P-lineage.
    Title: Cyclin CYB-3 controls both S-phase and mitosis and is asymmetrically distributed in the early C. elegans embryo.
  3. Mutations affecting dhc-1 and cyb-3 cooperate to increase fitness in the absence of MDF-1.
    Title: Cyclin B3 and dynein heavy chain cooperate to increase fitness in the absence of mdf-1/MAD1 in Caenorhabditis elegans.
  4. CYB-3 plays a unique, essential role in the cell cycle including promoting mitotic dynein functionality.
    Title: Caenorhabditis elegans cyclin B3 is required for multiple mitotic processes including alleviation of a spindle checkpoint-dependent block in anaphase chromosome segregation.
  5. Data show that doubling the CYB-3 (Cyclin B3) dosage suppresses sterility in the absence of the essential spindle assembly checkpoint component MDF-1 without causing a delay in the onset of anaphase.
    Title: Duplication of cyb-3 (cyclin B3) suppresses sterility in the absence of mdf-1/MAD1 spindle assembly checkpoint component in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables cyclin-dependent protein serine/threonine kinase regulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cyclin-dependent protein serine/threonine kinase regulator activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables cyclin-dependent protein serine/threonine kinase regulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in G1/S transition of mitotic cell cycle IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in cell division IEA
Inferred from Electronic Annotation
more info
  
involved_in centrosome cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in kinetochore organization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic cell cycle IEA
Inferred from Electronic Annotation
more info
  
involved_in meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in meiotic sister chromatid segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in mitotic cell cycle phase transition IEA
Inferred from Electronic Annotation
more info
  
involved_in mitotic sister chromatid segregation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within nematode male tail tip morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oocyte maturation IGI
Inferred from Genetic Interaction
more info
 PubMed 
involved_in positive regulation of mitotic metaphase/anaphase transition IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in positive regulation of protein phosphorylation IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in pronuclear migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of meiotic cell cycle IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
part_of cyclin-dependent protein kinase holoenzyme complex IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in microtubule organizing center IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
G2/mitotic-specific cyclin-B3
NP_001024112.2
  • Confirmed by transcript evidence
NP_506825.4
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    15395696..15397351
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001028941.4 → NP_001024112.2  G2/mitotic-specific cyclin-B3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024112.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q10654
    Conserved Domains (2) summary
    pfam00134
    Location:115 → 240
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:242 → 363
    Cyclin_C; Cyclin, C-terminal domain

  2. NM_074424.10 → NP_506825.4  G2/mitotic-specific cyclin-B3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506825.4

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q10654, Q95ZP8, Q9U378
    Conserved Domains (2) summary
    pfam00134
    Location:116 → 241
    Cyclin_N; Cyclin, N-terminal domain
    pfam02984
    Location:243 → 364
    Cyclin_C; Cyclin, C-terminal domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q10654.3

Gene LinkOut

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