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dpf-1 Dipeptidyl peptidase family member 1 [ Caenorhabditis elegans ]

Gene ID: 180042, updated on 2-Nov-2024

Summary

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Official Symbol
dpf-1
Official Full Name
Dipeptidyl peptidase family member 1
Primary source
WormBase:WBGene00001054
Locus tag
CELE_T23F1.7
See related
AllianceGenome:WB:WBGene00001054
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable dipeptidyl-peptidase activity. Predicted to be involved in proteolysis. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in Middle East respiratory syndrome; asthma; autosomal dominant intellectual developmental disorder 33; motor neuron disease (multiple); and type 2 diabetes mellitus. Orthologous to several human genes including DPP6 (dipeptidyl peptidase like 6). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dpf-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
11
Sequence:
Chromosome: V; NC_003283.11 (15471329..15476124)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene tRNA-Pro Neighboring gene ncRNA Neighboring gene Prion-like-(Q/N-rich)-domain-bearing protein Neighboring gene Alpha-1,6-mannosyl-glycoprotein 6-beta-N-acetylglucosaminyltransferase;Nucleotid_trans domain-containing protein;Nucleotide-diphospho-sugar transferase domain-containing protein Neighboring gene Nuclear hormone receptor family member nhr-150 Neighboring gene tRNA-Ala Neighboring gene tRNA-Tyr

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. A genomewide RNAi screen for genes that affect the stability, distribution and function of P granules in Caenorhabditis elegans. Updike DL, et al. Genetics, 2009 Dec. PMID 19805813, Free PMC Article
  2. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables aminopeptidase activity IEA
Inferred from Electronic Annotation
more info
  
enables dipeptidyl-peptidase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type peptidase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in proteolysis IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in proteolysis IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in plasma membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in plasma membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Dipeptidyl peptidase family member 1
NP_001256667.1
  • Confirmed by transcript evidence
NP_506850.1
  • Confirmed by transcript evidence
NP_506851.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    15471329..15476124
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_074449.6 → NP_506850.1  Dipeptidyl peptidase family member 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506850.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O18119, Q7JKY3
    Conserved Domains (3) summary
    COG1506
    Location:524 → 798
    DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
    pfam00326
    Location:615 → 795
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:182 → 507
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  2. NM_074450.7 → NP_506851.1  Dipeptidyl peptidase family member 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_506851.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q7JKY3
    Conserved Domains (3) summary
    COG1506
    Location:504 → 778
    DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
    pfam00326
    Location:595 → 775
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:162 → 487
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region

  3. NM_001269738.3 → NP_001256667.1  Dipeptidyl peptidase family member 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256667.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    D6R8X0
    Conserved Domains (3) summary
    COG1506
    Location:464 → 738
    DAP2; Dipeptidyl aminopeptidase/acylaminoacyl peptidase [Amino acid transport and metabolism]
    pfam00326
    Location:555 → 735
    Peptidase_S9; Prolyl oligopeptidase family
    pfam00930
    Location:122 → 447
    DPPIV_N; Dipeptidyl peptidase IV (DPP IV) N-terminal region
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q7JKY3.1

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