his-2 Histone H3 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: his-2
Official Full Name: Histone H3
Primary source: WormBase:WBGene00001876
Locus tag: CELE_T10C6.13
See related: AllianceGenome:WB:WBGene00001876
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables methylated histone binding activity. Predicted to be located in chromosome and nucleus. Predicted to be part of nucleosome. Is expressed in reproductive system. Orthologous to several human genes including H3C1 (H3 clustered histone 1); H3C10 (H3 clustered histone 10); and H3C11 (H3 clustered histone 11). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See his-2 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 1

Sequence:: Chromosome: V; NC_003283.11 (16041873..16042283, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

H3K4me2 regulates the recovery of protein biosynthesis and homeostasis following DNA damage.
Title: H3K4me2 regulates the recovery of protein biosynthesis and homeostasis following DNA damage.

Submit: New GeneRIF Correction

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

T10C6.14 (e-PCR)
- UniSTS:318477

T10C6.13 (e-PCR)
- UniSTS:320620

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables DNA binding	IEA Inferred from Electronic Annotation more info
enables methylated histone binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables protein heterodimerization activity	IEA Inferred from Electronic Annotation more info
enables structural constituent of chromatin	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
located_in chromosome	IEA Inferred from Electronic Annotation more info
part_of nucleosome	IEA Inferred from Electronic Annotation more info
located_in nucleus	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Histone H3

NP_507033.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

16041873..16042283 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_074632.5 → NP_507033.1 Histone H3 [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_507033.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P08898, Q9TW44

UniProtKB/TrEMBL

K7ZUH9

Conserved Domains (1) summary

PTZ00018
Location:1 → 136

PTZ00018; histone H3; Provisional