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cth-1 cystathionine gamma-lyase [ Caenorhabditis elegans ]

Gene ID: 180079, updated on 2-Nov-2024

Summary

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Official Symbol
cth-1
Official Full Name
cystathionine gamma-lyase
Primary source
WormBase:WBGene00009048
Locus tag
CELE_F22B8.6
See related
AllianceGenome:WB:WBGene00009048
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable cystathionine gamma-lyase activity and pyridoxal phosphate binding activity. Predicted to be involved in cysteine biosynthetic process via cystathionine and transsulfuration. Predicted to be active in cytoplasm. Human ortholog(s) of this gene implicated in amino acid metabolic disorder and cystathioninuria. Orthologous to human CTH (cystathionine gamma-lyase). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See cth-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
3
Sequence:
Chromosome: V; NC_003283.11 (16100680..16102750)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene MOSC domain-containing protein Neighboring gene G protein-coupled receptor;Seven TM Receptor Neighboring gene ncRNA Neighboring gene arginine kinase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Lifespan and healthspan benefits of exogenous H(2)S in C. elegans are independent from effects downstream of eat-2 mutation. Ng LT, et al. NPJ Aging Mech Dis, 2020. PMID 32566245, Free PMC Article
  2. Regulation of fatty acid desaturase- and immunity gene-expression by mbk-1/DYRK1A in Caenorhabditis elegans. Mack HID, et al. BMC Genomics, 2022 Jan 4. PMID 34983389, Free PMC Article
  3. ATF-4 and hydrogen sulfide signalling mediate longevity in response to inhibition of translation or mTORC1. Statzer C, et al. Nat Commun, 2022 Feb 18. PMID 35181679, Free PMC Article
  4. Sulfurous gases as biological messengers and toxins: comparative genetics of their metabolism in model organisms. Mathew ND, et al. J Toxicol, 2011. PMID 22131987, Free PMC Article
  5. Adult-restricted gene knock-down reveals candidates that affect locomotive healthspan in C. elegans. Jushaj A, et al. Biogerontology, 2023 Apr. PMID 36662373

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables L-cysteine desulfhydrase activity IEA
Inferred from Electronic Annotation
more info
  
enables L-cystine L-cysteine-lyase (deaminating) IEA
Inferred from Electronic Annotation
more info
  
enables carbon-sulfur lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables cystathionine gamma-lyase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables cystathionine gamma-lyase activity IEA
Inferred from Electronic Annotation
more info
  
enables pyridoxal phosphate binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables pyridoxal phosphate binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in cysteine biosynthetic process IEA
Inferred from Electronic Annotation
more info
  
involved_in cysteine biosynthetic process via cystathionine IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transsulfuration IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in transsulfuration IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

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Preferred Names
cystathionine gamma-lyase
NP_001263906.1
  • Confirmed by transcript evidence
NP_507053.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    16100680..16102750
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_074652.6 → NP_507053.1  cystathionine gamma-lyase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_507053.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O45391
    Conserved Domains (2) summary
    PRK09028
    Location:9 → 372
    PRK09028; cystathionine beta-lyase; Provisional
    pfam01053
    Location:8 → 372
    Cys_Met_Meta_PP; Cys/Met metabolizm PLP-dependent enzyme

  2. NM_001276977.3 → NP_001263906.1  cystathionine gamma-lyase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001263906.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    K8ESE2
    Conserved Domains (1) summary
    pfam01053
    Location:2 → 341
    Cys_Met_Meta_PP; Cys/Met metabolizm PLP-dependent enzyme
Nucleotide Protein
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