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dkf-2 Serine/threonine-protein kinase dkf-2 [ Caenorhabditis elegans ]

Gene ID: 180121, updated on 2-Nov-2024

Summary

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Official Symbol
dkf-2
Official Full Name
Serine/threonine-protein kinase dkf-2
Primary source
WormBase:WBGene00012019
Locus tag
CELE_T25E12.4
See related
AllianceGenome:WB:WBGene00012019
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables protein homodimerization activity and protein serine/threonine kinase activity. Involved in several processes, including defense response to bacterium; determination of adult lifespan; and phospholipase C-activating G protein-coupled receptor signaling pathway. Acts upstream of with a negative effect on protein import into nucleus. Located in cytoplasmic side of plasma membrane and cytosol. Part of serine/threonine protein kinase complex. Is expressed in intestine; neurons; pharynx; and spermathecal-uterine junction. Human ortholog(s) of this gene implicated in congenital heart disease. Orthologous to human PRKD1 (protein kinase D1); PRKD2 (protein kinase D2); and PRKD3 (protein kinase D3). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dkf-2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
21
Sequence:
Chromosome: V; NC_003283.11 (16747622..16788441)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene DUF38 domain-containing protein Neighboring gene glycogenin glucosyltransferase Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene MICOS complex subunit MIC60-2 Neighboring gene Pseudouridine synthase I TruA alpha/beta domain-containing protein;tRNA pseudouridine synthase Neighboring gene CTP synthase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Characterization of a novel protein kinase D: Caenorhabditis elegans DKF-1 is activated by translocation-phosphorylation and regulates movement and growth in vivo. Feng H, et al. J Biol Chem, 2006 Jun 30. PMID 16613841
  2. Speculations on the activation of ROS generation in C. elegans innate immune signaling. van der Hoeven R, et al. Worm, 2012 Jul 1. PMID 24058842, Free PMC Article
  3. Neuronal and intestinal protein kinase d isoforms mediate Na+ (salt taste)-induced learning. Fu Y, et al. Sci Signal, 2009 Aug 11. PMID 19671928
  4. Protein kinase D is an essential regulator of C. elegans innate immunity. Ren M, et al. Immunity, 2009 Apr 17. PMID 19371715, Free PMC Article
  5. A Novel Conserved Domain Mediates Dimerization of Protein Kinase D (PKD) Isoforms: DIMERIZATION IS ESSENTIAL FOR PKD-DEPENDENT REGULATION OF SECRETION AND INNATE IMMUNITY. Aicart-Ramos C, et al. J Biol Chem, 2016 Nov 4. PMID 27662904, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. DKF-2, a C. elegans PKD, regulates innate immunity
    Title: Protein kinase D is an essential regulator of C. elegans innate immunity.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables diacylglycerol-dependent serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables metal ion binding IEA
Inferred from Electronic Annotation
more info
  
enables protein homodimerization activity IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine kinase activity IEA
Inferred from Electronic Annotation
more info
  
enables protein serine/threonine kinase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables protein serine/threonine kinase activity IDA
Inferred from Direct Assay
more info
 PubMed 
enables protein serine/threonine kinase activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in antibacterial innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to Gram-negative bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in defense response to Gram-positive bacterium IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in determination of adult lifespan IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in innate immune response IEA
Inferred from Electronic Annotation
more info
  
involved_in innate immune response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in intracellular signal transduction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in intracellular signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phospholipase C-activating G protein-coupled receptor signaling pathway IGI
Inferred from Genetic Interaction
more info
 PubMed 
acts_upstream_of_negative_effect protein import into nucleus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein phosphorylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasmic side of plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
is_active_in cytosol IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytosol IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
part_of serine/threonine protein kinase complex IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Serine/threonine-protein kinase dkf-2
NP_001123022.1
  • Partially confirmed by transcript evidence
NP_001256724.1
  • Confirmed by transcript evidence
NP_001256725.1
  • Confirmed by transcript evidence
NP_001256726.1
  • Confirmed by transcript evidence
NP_001343593.1
  • Partially confirmed by transcript evidence
NP_507239.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    16747622..16788441
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_074838.7 → NP_507239.2  Serine/threonine-protein kinase dkf-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_507239.2

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    B1V8I6, G5EEQ6, H9G324, H9G325, O45818, O62166, O62167
    Conserved Domains (4) summary
    cd01239
    Location:618 → 728
    PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
    cd14082
    Location:766 → 1025
    STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
    cd20795
    Location:319 → 374
    C1_PKD_rpt1; first protein kinase C conserved region 1 (C1 domain) found in the protein kinase D (PKD) family
    cd20796
    Location:473 → 525
    C1_PKD_rpt2; second protein kinase C conserved region 1 (C1 domain) found in the family of protein kinase D (PKD)

  2. NM_001269796.3 → NP_001256725.1  Serine/threonine-protein kinase dkf-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256725.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O45818
    Conserved Domains (5) summary
    cd00029
    Location:474 → 523
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01239
    Location:643 → 753
    PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
    cd14082
    Location:791 → 1050
    STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
    pfam00069
    Location:798 → 1051
    Pkinase; Protein kinase domain
    pfam00130
    Location:326 → 371
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  3. NM_001269795.3 → NP_001256724.1  Serine/threonine-protein kinase dkf-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256724.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O45818
    Conserved Domains (5) summary
    cd00029
    Location:472 → 521
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01239
    Location:616 → 726
    PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
    cd14082
    Location:764 → 1023
    STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
    pfam00069
    Location:771 → 1024
    Pkinase; Protein kinase domain
    pfam00130
    Location:326 → 371
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  4. NM_001269797.3 → NP_001256726.1  Serine/threonine-protein kinase dkf-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256726.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O45818
    Conserved Domains (5) summary
    cd00029
    Location:252 → 301
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01239
    Location:396 → 506
    PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
    cd14082
    Location:544 → 803
    STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
    pfam00069
    Location:551 → 804
    Pkinase; Protein kinase domain
    pfam00130
    Location:104 → 149
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  5. NM_001129550.3 → NP_001123022.1  Serine/threonine-protein kinase dkf-2 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001123022.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    O45818
    Conserved Domains (5) summary
    cd00029
    Location:276 → 325
    C1; Protein kinase C conserved region 1 (C1) . Cysteine-rich zinc binding domain. Some members of this domain family bind phorbol esters and diacylglycerol, some are reported to bind RasGTP. May occur in tandem arrangement. Diacylglycerol (DAG) is a second ...
    cd01239
    Location:420 → 530
    PH_PKD; Protein kinase D (PKD/PKCmu) pleckstrin homology (PH) domain
    cd14082
    Location:568 → 827
    STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
    pfam00069
    Location:575 → 828
    Pkinase; Protein kinase domain
    pfam00130
    Location:128 → 173
    C1_1; Phorbol esters/diacylglycerol binding domain (C1 domain)

  6. NM_001356774.3 → NP_001343593.1  Serine/threonine-protein kinase dkf-2 [Caenorhabditis elegans]

    Status: REVIEWED

    Conserved Domains (1) summary
    cd14082
    Location:231 → 490
    STKc_PKD; Catalytic domain of the Serine/Threonine kinase, Protein Kinase D
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
O45818.4

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