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tni-3 Troponin I 3 [ Caenorhabditis elegans ]

Gene ID: 180127, updated on 18-Sep-2024

Summary

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Official Symbol
tni-3
Official Full Name
Troponin I 3
Primary source
WormBase:WBGene00006585
Locus tag
CELE_T20B3.2
See related
AllianceGenome:WB:WBGene00006585
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables troponin C binding activity. Involved in muscle contraction; oviposition; and post-embryonic body morphogenesis. Located in sarcomere. Is expressed in body wall musculature; non-striated muscle; rectal muscle; and in male. Orthologous to human TNNI1 (troponin I1, slow skeletal type). [provided by Alliance of Genome Resources, Apr 2022]
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Genomic context

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See tni-3 in Genome Data Viewer
Location:
chromosome: V
Exon count:
4
Sequence:
Chromosome: V; NC_003283.11 (16833638..16835128, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Serpentine Receptor, class H Neighboring gene Serpentine Receptor, class H Neighboring gene Fe2OG dioxygenase domain-containing protein Neighboring gene C-type lectin domain-containing protein Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Expression profiles and unc-27 mutation rescue of the striated muscle type troponin I isoform-3 in Caenorhabditis elegans. Takashima Y, et al. Genes Genet Syst, 2012. PMID 23229311
  2. Tissue expression of four troponin I genes and their molecular interactions with two troponin C isoforms in Caenorhabditis elegans. Ruksana R, et al. Genes Cells, 2005 Mar. PMID 15743415
  3. Tissue-specific interactions of TNI isoforms with other TN subunits and tropomyosins in C. elegans: the role of the C- and N-terminal extensions. Amin MZ, et al. Biochim Biophys Acta, 2007 Apr. PMID 17369112
  4. Tropomyosin and troponin are required for ovarian contraction in the Caenorhabditis elegans reproductive system. Ono K, et al. Mol Biol Cell, 2004 Jun. PMID 15064356, Free PMC Article
  5. Genes that control ray sensory neuron axon development in the Caenorhabditis elegans male. Jia L, et al. Genetics, 2006 Jul. PMID 16624900, Free PMC Article

See all (14) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TNI-3 was strongly expressed in head body-wall muscles and had an intermediated protein function among the three troponin I isoforms.
    Title: Expression profiles and unc-27 mutation rescue of the striated muscle type troponin I isoform-3 in Caenorhabditis elegans.
Submit: New GeneRIF Correction

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables actin binding IEA
Inferred from Electronic Annotation
more info
  
enables troponin C binding IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in egg-laying behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in muscle contraction IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in muscle contraction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in post-embryonic body morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
located_in myofibril HDA PubMed 
located_in sarcomere IDA
Inferred from Direct Assay
more info
 PubMed 
part_of troponin complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of troponin complex IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Troponin I 3
NP_507250.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    16833638..16835128 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_074849.9 → NP_507250.1  Troponin I 3 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_507250.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q5FBV4, Q9XUN9
    Conserved Domains (1) summary
    pfam00992
    Location:58 → 188
    Troponin; Troponin
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XUN9.1

Gene LinkOut

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