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dgat-2 Acyltransferase [ Caenorhabditis elegans ]

Gene ID: 180160, updated on 2-Nov-2024

Summary

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Official Symbol
dgat-2
Official Full Name
Acyltransferase
Primary source
WormBase:WBGene00010296
Locus tag
CELE_F59A1.10
See related
AllianceGenome:WB:WBGene00010296
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable diacylglycerol O-acyltransferase activity. Predicted to be involved in triglyceride biosynthetic process. Located in lipid droplet. Orthologous to several human genes including MOGAT1 (monoacylglycerol O-acyltransferase 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See dgat-2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
2
Sequence:
Chromosome: V; NC_003283.11 (17660303..17661810)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene F-box domain-containing protein Neighboring gene tRNA Neighboring gene tRNA Neighboring gene Serpentine Receptor, class H;Serpentine Receptor, class T Neighboring gene tRNA Neighboring gene pseudo

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. S-Adenosyl methionine synthetase 1 limits fat storage in Caenorhabditis elegans. Ehmke M, et al. Genes Nutr, 2014 Mar. PMID 24510589, Free PMC Article
  2. The FATP1-DGAT2 complex facilitates lipid droplet expansion at the ER-lipid droplet interface. Xu N, et al. J Cell Biol, 2012 Sep 3. PMID 22927462, Free PMC Article
  3. Early-life perfluorooctanoic acid (PFOA) and perfluorooctane sulfonic acid (PFOS) exposure cause obesity by disrupting fatty acids metabolism and enhancing triglyceride synthesis in Caenorhabditis elegans. Lin TA, et al. Aquat Toxicol, 2022 Oct. PMID 36037606
  4. Neuronal control of lipid metabolism by STR-2 G protein-coupled receptor promotes longevity in Caenorhabditis elegans. Dixit A, et al. Aging Cell, 2020 Jun. PMID 32432390, Free PMC Article
  5. PHA-4/FoxA senses nucleolar stress to regulate lipid accumulation in Caenorhabditis elegans. Wu J, et al. Nat Commun, 2018 Mar 22. PMID 29567958, Free PMC Article

See all (18) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables O-acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables acyltransferase activity IEA
Inferred from Electronic Annotation
more info
  
enables diacylglycerol O-acyltransferase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
Process Evidence Code Pubs
involved_in triglyceride biosynthetic process IBA
Inferred from Biological aspect of Ancestor
more info
  
Component Evidence Code Pubs
located_in endoplasmic reticulum IEA
Inferred from Electronic Annotation
more info
  
is_active_in endoplasmic reticulum membrane IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in endoplasmic reticulum membrane IEA
Inferred from Electronic Annotation
more info
  
located_in lipid droplet IDA
Inferred from Direct Assay
more info
 PubMed 
located_in membrane IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Acyltransferase
NP_507469.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    17660303..17661810
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_075068.5 → NP_507469.1  Acyltransferase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_507469.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    Q9XUW0
    Conserved Domains (1) summary
    pfam03982
    Location:50 → 345
    DAGAT; Diacylglycerol acyltransferase
Nucleotide Protein
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