Y39B6A.3 Iron-sulfur cluster assembly 1 homolog, mitochondrial [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: Y39B6A.3
Official Full Name: Iron-sulfur cluster assembly 1 homolog, mitochondrial
Primary source: WormBase:WBGene00012666
Locus tag: CELE_Y39B6A.3
See related: AllianceGenome:WB:WBGene00012666
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Predicted to enable 2 iron, 2 sulfur cluster binding activity. Predicted to be involved in iron-sulfur cluster assembly and protein maturation by iron-sulfur cluster transfer. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in multiple mitochondrial dysfunctions syndrome 5. Orthologous to human ISCA1 (iron-sulfur cluster assembly 1). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See Y39B6A.3 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 4

Sequence:: Chromosome: V; NC_003283.11 (19189245..19190013, complement)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y39B6B.ee (e-PCR)
- UniSTS:322788

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables 2 iron, 2 sulfur cluster binding	IBA Inferred from Biological aspect of Ancestor more info
enables iron-sulfur cluster binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in iron-sulfur cluster assembly	IBA Inferred from Biological aspect of Ancestor more info
involved_in iron-sulfur cluster assembly	IEA Inferred from Electronic Annotation more info
involved_in protein maturation by iron-sulfur cluster transfer	IBA Inferred from Biological aspect of Ancestor more info

Component	Evidence Code	Pubs
is_active_in cytoplasm	IBA Inferred from Biological aspect of Ancestor more info
is_active_in mitochondrion	IBA Inferred from Biological aspect of Ancestor more info

General protein information

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Preferred Names: Iron-sulfur cluster assembly 1 homolog, mitochondrial

NP_001123038.1

Confirmed by transcript evidence

NP_741696.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

19189245..19190013 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001129566.4 → NP_001123038.1 Iron-sulfur cluster assembly 1 homolog, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001123038.1

Status: REVIEWED

UniProtKB/TrEMBL

A5HWB2

Conserved Domains (1) summary

TIGR00049
Location:28 → 131

TIGR00049; Iron-sulfur cluster assembly accessory protein
NM_171606.6 → NP_741696.1 Iron-sulfur cluster assembly 1 homolog, mitochondrial [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_741696.1

Status: REVIEWED

UniProtKB/TrEMBL

Q9NES9

Conserved Domains (1) summary

TIGR00049
Location:26 → 129

TIGR00049; Iron-sulfur cluster assembly accessory protein