pph-5 Serine/threonine specific protein phosphatases domain-containing protein;Serine/threonine-protein phosphatase 5 [Caenorhabditis elegans] - Gene

Summary

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Official Symbol: pph-5
Official Full Name: Serine/threonine specific protein phosphatases domain-containing protein;Serine/threonine-protein phosphatase 5
Primary source: WormBase:WBGene00012665
Locus tag: CELE_Y39B6A.2
See related: AllianceGenome:WB:WBGene00012665
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Caenorhabditis elegans (strain: Bristol N2)
Lineage: Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary: Enables Hsp90 protein binding activity and phosphoprotein phosphatase activity. Involved in negative regulation of exocytosis and protein localization to organelle. Located in cytoplasm and mitotic spindle. Part of protein-containing complex. Is expressed in several structures, including intestine. Orthologous to human PPP5C (protein phosphatase 5 catalytic subunit). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See pph-5 in Genome Data Viewer

Location:: chromosome: V

Exon count:: 8

Sequence:: Chromosome: V; NC_003283.11 (19190547..19199272)

Chromosome V - NC_003283.11 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The activity of protein phosphatase 5 towards native clients, such as glucocorticoid receptor, is modulated by the middle- and C-terminal domains of Hsp90.
Title: The activity of protein phosphatase 5 towards native clients is modulated by the middle- and C-terminal domains of Hsp90.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Markers

Y39B6B.ee (e-PCR)
- UniSTS:322788

Y39B6B.ff (e-PCR)
- UniSTS:324072

Homology

Orthologs from OrthoDB

Gene Ontology Provided by WormBase

Function	Evidence Code	Pubs
enables Hsp90 protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables hydrolase activity	IEA Inferred from Electronic Annotation more info
enables metal ion binding	IEA Inferred from Electronic Annotation more info
enables myosin phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphatase activity	IEA Inferred from Electronic Annotation more info
enables phosphoprotein phosphatase activity	IDA Inferred from Direct Assay more info	PubMed
enables phosphoprotein phosphatase activity	IEA Inferred from Electronic Annotation more info
enables protein serine/threonine phosphatase activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein serine/threonine phosphatase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in negative regulation of exocytosis	IGI Inferred from Genetic Interaction more info	PubMed
involved_in protein localization to organelle	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	IDA Inferred from Direct Assay more info	PubMed
located_in cytoplasm	IEA Inferred from Electronic Annotation more info
located_in cytoskeleton	IEA Inferred from Electronic Annotation more info
is_active_in cytosol	IBA Inferred from Biological aspect of Ancestor more info
located_in mitotic spindle	IDA Inferred from Direct Assay more info	PubMed
is_active_in nucleus	IBA Inferred from Biological aspect of Ancestor more info
part_of protein-containing complex	IDA Inferred from Direct Assay more info	PubMed
located_in spindle	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: Serine/threonine specific protein phosphatases domain-containing protein;Serine/threonine-protein phosphatase 5

NP_001256850.1

Confirmed by transcript evidence

NP_001367002.1

Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003283.11 Reference assembly

Range

19190547..19199272

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001380870.1 → NP_001367002.1 Serine/threonine-protein phosphatase 5 [Caenorhabditis elegans]

Status: REVIEWED

UniProtKB/Swiss-Prot

Q9NES8

Conserved Domains (3) summary

PLN03088
Location:29 → 139

PLN03088; SGT1, suppressor of G2 allele of SKP1; Provisional

sd00006
Location:33 → 57

TPR; TPR repeat [structural motif]

cd07417
Location:176 → 490

MPP_PP5_C; PP5, C-terminal metallophosphatase domain
NM_001269921.3 → NP_001256850.1 Serine/threonine specific protein phosphatases domain-containing protein [Caenorhabditis elegans]

See identical proteins and their annotated locations for NP_001256850.1

Status: REVIEWED

UniProtKB/TrEMBL

E0R7L7

Conserved Domains (1) summary

cl13995
Location:1 → 111

MPP_superfamily; metallophosphatase superfamily, metallophosphatase domain