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fars-2 FDX-ACB domain-containing protein;phenylalanine--tRNA ligase [ Caenorhabditis elegans ]

Gene ID: 180303, updated on 2-Nov-2024

Summary

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Official Symbol
fars-2
Official Full Name
FDX-ACB domain-containing protein;phenylalanine--tRNA ligase
Primary source
WormBase:WBGene00013361
Locus tag
CELE_Y60A3A.13
See related
AllianceGenome:WB:WBGene00013361
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable phenylalanine-tRNA ligase activity. Predicted to be involved in phenylalanyl-tRNA aminoacylation. Predicted to be located in mitochondrial matrix. Predicted to be active in mitochondrion. Human ortholog(s) of this gene implicated in combined oxidative phosphorylation deficiency 14 and hereditary spastic paraplegia 77. Orthologous to human FARS2 (phenylalanyl-tRNA synthetase 2, mitochondrial). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See fars-2 in Genome Data Viewer
Location:
chromosome: V
Exon count:
9
Sequence:
Chromosome: V; NC_003283.11 (19897977..19907434, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene SCP domain-containing protein Neighboring gene Polypeptide N-acetylgalactosaminyltransferase 4;polypeptide N-acetylgalactosaminyltransferase Neighboring gene ncRNA Neighboring gene Protein kinase domain-containing protein Neighboring gene ncRNA Neighboring gene Serine/threonine-protein kinase chk-2 Neighboring gene Protein YIPF

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Carbohydrates and glycosylation. Berninsone PM. WormBook, 2006 Dec 18. PMID 18050430, Free PMC Article
  2. Amino acid and protein specificity of protein fatty acylation in C. elegans. Zhang B, et al. Proc Natl Acad Sci U S A, 2024 Jan 30. PMID 38252833, Free PMC Article
  3. OrthoList: a compendium of C. elegans genes with human orthologs. Shaye DD, et al. PLoS One, 2011. PMID 21647448, Free PMC Article
  4. OrthoList 2: A New Comparative Genomic Analysis of Human and Caenorhabditis elegans Genes. Kim W, et al. Genetics, 2018 Oct. PMID 30120140, Free PMC Article
  5. Genome sequence of the nematode C. elegans: a platform for investigating biology. C. elegans Sequencing Consortium. Science, 1998 Dec 11. PMID 9851916

GeneRIFs: Gene References Into Functions

General gene information

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Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATP binding IEA
Inferred from Electronic Annotation
more info
  
enables aminoacyl-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables nucleotide binding IEA
Inferred from Electronic Annotation
more info
  
enables phenylalanine-tRNA ligase activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables phenylalanine-tRNA ligase activity IEA
Inferred from Electronic Annotation
more info
  
enables tRNA binding IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in phenylalanyl-tRNA aminoacylation IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in phenylalanyl-tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
involved_in tRNA aminoacylation IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in cytoplasm IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in mitochondrial matrix IEA
Inferred from Electronic Annotation
more info
  
is_active_in mitochondrion IBA
Inferred from Biological aspect of Ancestor
more info
  
located_in mitochondrion IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
FDX-ACB domain-containing protein;phenylalanine--tRNA ligase
NP_001123055.1
  • Confirmed by transcript evidence
NP_001367255.1
  • Confirmed by transcript evidence
NP_507852.2
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    19897977..19907434 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_075451.6 → NP_507852.2  phenylalanine--tRNA ligase [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_507852.2

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5ECI8
    Conserved Domains (1) summary
    PLN02788
    Location:22 → 458
    PLN02788; phenylalanine-tRNA synthetase

  2. NM_001380876.1 → NP_001367255.1  phenylalanine--tRNA ligase [Caenorhabditis elegans]

    Status: REVIEWED

    UniProtKB/TrEMBL
    G5EEN1
    Conserved Domains (1) summary
    PLN02788
    Location:2 → 428
    PLN02788; phenylalanine-tRNA synthetase

  3. NM_001129583.4 → NP_001123055.1  FDX-ACB domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001123055.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B1V8K6
    Conserved Domains (1) summary
    smart00896
    Location:3 → 74
    FDX-ACB; Ferredoxin-fold anticodon binding domain
Nucleotide Protein
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