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Nfix nuclear factor I/X [ Mus musculus (house mouse) ]

Gene ID: 18032, updated on 28-Oct-2024

Summary

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Official Symbol
Nfixprovided by MGI
Official Full Name
nuclear factor I/Xprovided by MGI
Primary source
MGI:MGI:97311
See related
Ensembl:ENSMUSG00000001911 AllianceGenome:MGI:97311
Gene type
protein coding
RefSeq status
VALIDATED
Organism
Mus musculus
Lineage
Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as
CTF; NF1-X; NFI-X; NF-I/X
Summary
Enables DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and chromatin binding activity. Involved in several processes, including learning or memory; nervous system development; and regulation of DNA-templated transcription. Acts upstream of or within several processes, including exit from mitosis; myeloid leukocyte differentiation; and nervous system development. Is active in nucleus. Is expressed in several structures, including alimentary system; central nervous system; genitourinary system; respiratory system; and sensory organ. Used to study Scheuermann's disease and Sotos syndrome 2. Human ortholog(s) of this gene implicated in Marshall-Smith syndrome and Sotos syndrome 2. Orthologous to human NFIX (nuclear factor I X). [provided by Alliance of Genome Resources, Oct 2024]
Expression
Ubiquitous expression in lung adult (RPKM 15.5), limb E14.5 (RPKM 14.4) and 25 other tissues See more
Orthologs
human all
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Genomic context

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See Nfix in Genome Data Viewer
Location:
8 C3; 8 41.02 cM
Exon count:
18
Annotation release Status Assembly Chr Location
RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (85431341..85527086, complement)
108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (84704712..84801238, complement)

Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:87188874-87189057 Neighboring gene predicted gene, 26664 Neighboring gene nucleus accumbens associated 1, BEN and BTB (POZ) domain containing Neighboring gene STARR-positive B cell enhancer ABC_E6667 Neighboring gene STARR-positive B cell enhancer ABC_E5026 Neighboring gene tRNA methyltransferase 1 Neighboring gene CapStarr-seq enhancer MGSCv37_chr8:87228416-87228525 Neighboring gene RIKEN cDNA G430095P16 gene Neighboring gene lymphoblastomic leukemia 1 Neighboring gene VISTA enhancer mm21 Neighboring gene VISTA enhancer mm1615 Neighboring gene STARR-seq mESC enhancer starr_22139 Neighboring gene DAN domain family member 5, BMP antagonist Neighboring gene growth arrest and DNA-damage-inducible, gamma interacting protein 1 Neighboring gene RAD23 homolog A, nucleotide excision repair protein

Genomic regions, transcripts, and products

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Go to nucleotide: Graphics FASTA GenBank

Expression

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  • Project title: Mouse ENCODE transcriptome data Mouse ENCODE transcriptome data
  • Description: RNA profiling data sets generated by the Mouse ENCODE project.
  • BioProject: PRJNA66167
  • Publication: PMID 25409824
  • Analysis date: n/a

Bibliography

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Related articles in PubMed

  1. Analysis of hippocampal-dependent learning and memory behaviour in mice lacking Nfix from adult neural stem cells. Zalucki O, et al. BMC Res Notes, 2018 Aug 6. PMID 30081965, Free PMC Article
  2. Nuclear factor I X deficiency causes brain malformation and severe skeletal defects. Driller K, et al. Mol Cell Biol, 2007 May. PMID 17353270, Free PMC Article
  3. NFIX--one gene, two knockouts, multiple effects. Pekarik V, et al. J Biol, 2008 Oct 23. PMID 18983696, Free PMC Article
  4. Alterations in gene expression in the spinal cord of mice lacking Nfix. Matuzelski E, et al. BMC Res Notes, 2020 Sep 16. PMID 32938475, Free PMC Article
  5. Heterozygosity for Nuclear Factor One X in mice models features of Malan syndrome. Oishi S, et al. EBioMedicine, 2019 Jan. PMID 30503862, Free PMC Article

See all (115) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. Function and regulation of nuclear factor 1 X-type on chondrocyte proliferation and differentiation.
    Title: Function and regulation of nuclear factor 1 X-type on chondrocyte proliferation and differentiation.
  2. Hydrocephalus in Nfix(-/-) Mice Is Underpinned by Changes in Ependymal Cell Physiology.
    Title: Hydrocephalus in Nfix(-/-) Mice Is Underpinned by Changes in Ependymal Cell Physiology.
  3. Deletion of NFIX results in defective progression through meiosis within the mouse testisdagger.
    Title: Deletion of NFIX results in defective progression through meiosis within the mouse testis†.
  4. Selective ablation of Nfix in macrophages attenuates muscular dystrophy by inhibiting fibro-adipogenic progenitor-dependent fibrosis.
    Title: Selective ablation of Nfix in macrophages attenuates muscular dystrophy by inhibiting fibro-adipogenic progenitor-dependent fibrosis.
  5. High-mobility group AT-Hook 1 mediates the role of nuclear factor I/X in osteogenic differentiation through activating canonical Wnt signaling.
    Title: High-mobility group AT-Hook 1 mediates the role of nuclear factor I/X in osteogenic differentiation through activating canonical Wnt signaling.
  6. Temporarily Epigenetic Repression in Bergmann Glia Regulates the Migration of Granule Cells.
    Title: Temporarily Epigenetic Repression in Bergmann Glia Regulates the Migration of Granule Cells.
  7. The Transcription Factor Nfix Requires RhoA-ROCK1 Dependent Phagocytosis to Mediate Macrophage Skewing during Skeletal Muscle Regeneration.
    Title: The Transcription Factor Nfix Requires RhoA-ROCK1 Dependent Phagocytosis to Mediate Macrophage Skewing during Skeletal Muscle Regeneration.
  8. MicroRNA-25-3p regulates osteoclasts through nuclear factor I X.
    Title: MicroRNA-25-3p regulates osteoclasts through nuclear factor I X.
  9. Removal of Nfix gene from either neural stem and progenitor cells, or neuroblasts, within the ventricular-subventricular zone culminated in neuroblast migration defects. Mechanistically, we identified aberrant neuroblast branching, due in part to increased expression of the guanylyl cyclase natriuretic peptide receptor 2 (Npr2), as a factor contributing to abnormal migration in Nfix-deficient adult mice.
    Title: NFIX-Mediated Inhibition of Neuroblast Branching Regulates Migration Within the Adult Mouse Ventricular-Subventricular Zone.
  10. The NFI transcription factors (Nfia, Nfib, and Nfix) are selectively expressed in late retinal progenitor cells and they control bipolar interneuron and Muller glia cell fate specification and promote proliferative quiescence.
    Title: Single-Cell RNA-Seq Analysis of Retinal Development Identifies NFI Factors as Regulating Mitotic Exit and Late-Born Cell Specification.
Submit: New GeneRIF Correction See all GeneRIFs (38)

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics  (MGI)

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by MGI

Function Evidence Code Pubs
enables DNA-binding transcription activator activity, RNA polymerase II-specific IDA
Inferred from Direct Assay
more info
 PubMed 
enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
Inferred from Biological aspect of Ancestor
more info
  
enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables RNA polymerase II transcription regulatory region sequence-specific DNA binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IDA
Inferred from Direct Assay
more info
 PubMed 
enables chromatin binding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables sequence-specific double-stranded DNA binding ISO
Inferred from Sequence Orthology
more info
  
Process Evidence Code Pubs
involved_in DNA replication IEA
Inferred from Electronic Annotation
more info
  
acts_upstream_of_or_within Rho protein signal transduction IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within astrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in astrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in atrioventricular canal morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in bone mineralization IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in brain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within brain morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in camera-type eye development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell maturation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell proliferation in forebrain IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in cell proliferation in forebrain IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cell quiescence IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cell quiescence IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cellular response to BMP stimulus IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cerebellar Purkinje cell layer development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cerebellar cortex morphogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cerebellar granule cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cerebellar granule cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within cerebellum development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in cerebral cortex development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within collateral sprouting IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in ear development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in endochondral ossification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in epithelium development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within exit from mitosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within forebrain development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in forebrain radial glial cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within gene expression IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gene expression IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within generation of neurons IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in glial cell development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within glial cell fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within glial cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in gliogenesis IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in gliogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in hippocampus development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in homeostasis of number of cells within a tissue IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within inflammatory response IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within lateral ventricle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in lateral ventricle development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in learning IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within macrophage differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in memory IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in multicellular organism growth IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of neuron apoptotic process IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in negative regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within neural precursor cell proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuroblast differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuroblast migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuroblast migration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuroblast proliferation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neurogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neurogenesis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in neuron differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within neuron fate specification IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in olfactory bulb development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in oligodendrocyte differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within osteoclast differentiation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within osteoclast proliferation IDA
Inferred from Direct Assay
more info
 PubMed 
acts_upstream_of_or_within phagocytosis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in positive regulation of transcription by RNA polymerase II ISO
Inferred from Sequence Orthology
more info
  
acts_upstream_of_or_within regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of DNA-binding transcription factor activity IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
acts_upstream_of_or_within response to wounding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in response to wounding IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within retina development in camera-type eye IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in skeletal muscle satellite cell differentiation IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in skeletal muscle tissue development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within skeletal muscle tissue regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in skeletal muscle tissue regeneration IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in skeletal system development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within social behavior IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in spinal cord development IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within stem cell population maintenance IMP
Inferred from Mutant Phenotype
more info
 PubMed 
acts_upstream_of_or_within tissue homeostasis IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in transcription by RNA polymerase II IDA
Inferred from Direct Assay
more info
 PubMed 
involved_in transcription by RNA polymerase II IMP
Inferred from Mutant Phenotype
more info
 PubMed 
Component Evidence Code Pubs
is_active_in nucleus IBA
Inferred from Biological aspect of Ancestor
more info
  
is_active_in nucleus IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
nuclear factor 1 X-type
Names
CCAAT-box-binding transcription factor
TGGCA-binding protein
nuclear factor 1/X

NCBI Reference Sequences (RefSeq)

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NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

  1. NM_001081981.3 → NP_001075450.1  nuclear factor 1 X-type isoform 3

    Status: VALIDATED

    Description
    Transcript Variant: This variant (3) encodes isoform 3.
    Source sequence(s)
    AC145556, AC155163
    Consensus CDS
    CCDS40411.1
    UniProtKB/TrEMBL
    E9PUH7, Q5CZY4
    Related
    ENSMUSP00000105386.2, ENSMUST00000109764.8
    Conserved Domains (3) summary
    pfam00859
    Location:205 → 494
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:2 → 38
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:60 → 162
    MH1; N-terminal Mad Homology 1 (MH1) domain

  2. NM_001081982.3 → NP_001075451.1  nuclear factor 1 X-type isoform 1

    See identical proteins and their annotated locations for NP_001075451.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (1) differs in the 5' UTR, initiates translation at an alternate start codon, and has multiple coding region differences, compared to variant 3. The encoded isoform (1) has a distinct N-terminus and is shorter than isoform 3.
    Source sequence(s)
    AC145556, AC155163
    Consensus CDS
    CCDS40413.1
    UniProtKB/Swiss-Prot
    O08519, P70257, P70258, Q64192, Q99L78, Q9R1G2
    UniProtKB/TrEMBL
    D3YZ00
    Related
    ENSMUSP00000096669.4, ENSMUST00000099070.10
    Conserved Domains (3) summary
    pfam00859
    Location:213 → 418
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:9 → 46
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:68 → 170
    MH1; N-terminal Mad Homology 1 (MH1) domain

  3. NM_001297601.2 → NP_001284530.1  nuclear factor 1 X-type isoform 4

    See identical proteins and their annotated locations for NP_001284530.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (4) lacks an alternate in-frame exon and another alternate exon compared to variant 3, that causes a frameshift. The resulting isoform (4) has a shorter and distinct C-terminus and lacks an alternate internal segment compared to isoform 3.
    Source sequence(s)
    AC145556, AC155163
    Consensus CDS
    CCDS80907.1
    UniProtKB/TrEMBL
    Q3TYK3
    Related
    ENSMUSP00000105384.2, ENSMUST00000109762.8
    Conserved Domains (3) summary
    pfam00859
    Location:205 → 368
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:2 → 38
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:60 → 162
    MH1; N-terminal Mad Homology 1 (MH1) domain

  4. NM_001371052.1 → NP_001357981.1  nuclear factor 1 X-type isoform 5

    Status: VALIDATED

    Description
    Transcript Variant: This variant (5) encodes the longest isoform (5).
    Source sequence(s)
    AC145556, AC155163
    UniProtKB/TrEMBL
    Q5CZY4
    Conserved Domains (3) summary
    pfam00859
    Location:216 → 505
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:13 → 49
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:71 → 173
    MH1; N-terminal Mad Homology 1 (MH1) domain

  5. NM_001371053.1 → NP_001357982.1  nuclear factor 1 X-type isoform 6

    Status: VALIDATED

    Source sequence(s)
    AC145556, AC155163
    UniProtKB/TrEMBL
    D3YZ00
    Conserved Domains (3) summary
    pfam10524
    Location:9 → 46
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    pfam00859
    Location:213 → 502
    CTF_NFI; CTF/NF-I family transcription modulation region
    cl00055
    Location:68 → 170
    MH1; N-terminal Mad Homology 1 (MH1) domain

  6. NM_001371054.1 → NP_001357983.1  nuclear factor 1 X-type isoform 7

    Status: VALIDATED

    Source sequence(s)
    AC145556, AC155163
    UniProtKB/TrEMBL
    Q5CZY4
    Conserved Domains (3) summary
    pfam10524
    Location:6 → 42
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    pfam00859
    Location:209 → 498
    CTF_NFI; CTF/NF-I family transcription modulation region
    cl00055
    Location:64 → 166
    MH1; N-terminal Mad Homology 1 (MH1) domain

  7. NM_001371055.1 → NP_001357984.1  nuclear factor 1 X-type isoform 8

    Status: VALIDATED

    Source sequence(s)
    AC145556, AC155163
    UniProtKB/TrEMBL
    Q5CZY4
    Conserved Domains (3) summary
    pfam00859
    Location:205 → 453
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:2 → 38
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:60 → 162
    MH1; N-terminal Mad Homology 1 (MH1) domain

  8. NM_001371056.1 → NP_001357985.1  nuclear factor 1 X-type isoform 9

    Status: VALIDATED

    Source sequence(s)
    AC145556, AC155163
    UniProtKB/Swiss-Prot
    O08519, P70257, P70258, Q64192, Q99L78, Q9R1G2
    UniProtKB/TrEMBL
    D3YZ00
    Conserved Domains (3) summary
    pfam00859
    Location:216 → 421
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:9 → 49
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:71 → 173
    MH1; N-terminal Mad Homology 1 (MH1) domain

  9. NM_001371057.1 → NP_001357986.1  nuclear factor 1 X-type isoform 10

    Status: VALIDATED

    Source sequence(s)
    AC145556, AC155163
    UniProtKB/Swiss-Prot
    O08519, P70257, P70258, Q64192, Q99L78, Q9R1G2
    UniProtKB/TrEMBL
    D3YZ00
    Conserved Domains (3) summary
    pfam00859
    Location:205 → 410
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:2 → 38
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:60 → 162
    MH1; N-terminal Mad Homology 1 (MH1) domain

  10. NM_001371058.1 → NP_001357987.1  nuclear factor 1 X-type isoform 11

    Status: VALIDATED

    Source sequence(s)
    AC145556, AC155163
    UniProtKB/Swiss-Prot
    O08519, P70257, P70258, Q64192, Q99L78, Q9R1G2
    UniProtKB/TrEMBL
    D3YZ00
    Conserved Domains (3) summary
    pfam00859
    Location:205 → 409
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:2 → 38
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:60 → 162
    MH1; N-terminal Mad Homology 1 (MH1) domain

  11. NM_001371059.1 → NP_001357988.1  nuclear factor 1 X-type isoform 12

    Status: VALIDATED

    Source sequence(s)
    AC145556, AC155163
    UniProtKB/Swiss-Prot
    O08519, P70257, P70258, Q64192, Q99L78, Q9R1G2
    UniProtKB/TrEMBL
    D3YZ00
    Conserved Domains (3) summary
    pfam00859
    Location:209 → 414
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:6 → 42
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:64 → 166
    MH1; N-terminal Mad Homology 1 (MH1) domain

  12. NM_001371060.1 → NP_001357989.1  nuclear factor 1 X-type isoform 13

    Status: VALIDATED

    Source sequence(s)
    AC145556, AC155163
    Conserved Domains (2) summary
    pfam00859
    Location:166 → 370
    CTF_NFI; CTF/NF-I family transcription modulation region
    cl00055
    Location:21 → 123
    MH1; N-terminal Mad Homology 1 (MH1) domain

  13. NM_001371061.1 → NP_001357990.1  nuclear factor 1 X-type isoform 14

    Status: VALIDATED

    Source sequence(s)
    AC145556, AC155163
    Conserved Domains (3) summary
    pfam00859
    Location:205 → 382
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:2 → 38
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:60 → 162
    MH1; N-terminal Mad Homology 1 (MH1) domain

  14. NM_001371062.1 → NP_001357991.1  nuclear factor 1 X-type isoform 15

    Status: VALIDATED

    Description
    Transcript Variant: This variant (15), as well as variant 16, encodes isoform 15.
    Source sequence(s)
    AC145556, AC155163
    Conserved Domains (2) summary
    pfam00859
    Location:166 → 371
    CTF_NFI; CTF/NF-I family transcription modulation region
    cl00055
    Location:21 → 123
    MH1; N-terminal Mad Homology 1 (MH1) domain

  15. NM_001371063.1 → NP_001357992.1  nuclear factor 1 X-type isoform 15

    Status: VALIDATED

    Description
    Transcript Variant: This variant (16), as well as variant 15, encodes isoform 15.
    Source sequence(s)
    AC145556, AC155163
    Conserved Domains (2) summary
    pfam00859
    Location:166 → 371
    CTF_NFI; CTF/NF-I family transcription modulation region
    cl00055
    Location:21 → 123
    MH1; N-terminal Mad Homology 1 (MH1) domain

  16. NM_010906.4 → NP_035036.1  nuclear factor 1 X-type isoform 2

    See identical proteins and their annotated locations for NP_035036.1

    Status: VALIDATED

    Description
    Transcript Variant: This variant (2) differs in the 5' UTR, initiates translation at an alternate start codon, and has multiple coding region differences, compared to variant 3. The encoded isoform (1) has a distinct N-terminus and is shorter than isoform 3.
    Source sequence(s)
    AC145556, AC155163
    Consensus CDS
    CCDS40412.1
    UniProtKB/Swiss-Prot
    P70257
    UniProtKB/TrEMBL
    Q3TYK3, Q5CZY4
    Related
    ENSMUSP00000076005.7, ENSMUST00000076715.13
    Conserved Domains (3) summary
    pfam00859
    Location:213 → 390
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:9 → 46
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:68 → 170
    MH1; N-terminal Mad Homology 1 (MH1) domain

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

  1. NC_000074.7 Reference GRCm39 C57BL/6J

    Range
    85431341..85527086 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. XM_036153804.1 → XP_036009697.1  nuclear factor 1 X-type isoform X15

    UniProtKB/Swiss-Prot
    O08519, P70257, P70258, Q64192, Q99L78, Q9R1G2
    UniProtKB/TrEMBL
    D3YZ00
    Conserved Domains (3) summary
    pfam10524
    Location:9 → 46
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    pfam00859
    Location:213 → 418
    CTF_NFI; CTF/NF-I family transcription modulation region
    cl00055
    Location:68 → 170
    MH1; N-terminal Mad Homology 1 (MH1) domain

  2. XM_036153796.1 → XP_036009689.1  nuclear factor 1 X-type isoform X5

    Conserved Domains (2) summary
    pfam00859
    Location:166 → 371
    CTF_NFI; CTF/NF-I family transcription modulation region
    cl00055
    Location:21 → 123
    MH1; N-terminal Mad Homology 1 (MH1) domain

  3. XM_036153797.1 → XP_036009690.1  nuclear factor 1 X-type isoform X6

    Conserved Domains (2) summary
    pfam00859
    Location:166 → 370
    CTF_NFI; CTF/NF-I family transcription modulation region
    cl00055
    Location:21 → 123
    MH1; N-terminal Mad Homology 1 (MH1) domain

  4. XM_036153805.1 → XP_036009698.1  nuclear factor 1 X-type isoform X16

    UniProtKB/Swiss-Prot
    O08519, P70257, P70258, Q64192, Q99L78, Q9R1G2
    UniProtKB/TrEMBL
    D3YZ00
    Conserved Domains (3) summary
    pfam10524
    Location:2 → 38
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    pfam00859
    Location:205 → 410
    CTF_NFI; CTF/NF-I family transcription modulation region
    cl00055
    Location:60 → 162
    MH1; N-terminal Mad Homology 1 (MH1) domain

  5. XM_036153799.1 → XP_036009692.1  nuclear factor 1 X-type isoform X10

    UniProtKB/TrEMBL
    Q5CZY4
    Conserved Domains (3) summary
    pfam10524
    Location:6 → 42
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    pfam00859
    Location:209 → 498
    CTF_NFI; CTF/NF-I family transcription modulation region
    cl00055
    Location:64 → 166
    MH1; N-terminal Mad Homology 1 (MH1) domain

  6. XM_036153802.1 → XP_036009695.1  nuclear factor 1 X-type isoform X13

    UniProtKB/Swiss-Prot
    O08519, P70257, P70258, Q64192, Q99L78, Q9R1G2
    UniProtKB/TrEMBL
    D3YZ00
    Conserved Domains (3) summary
    pfam10524
    Location:9 → 46
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    pfam00859
    Location:213 → 417
    CTF_NFI; CTF/NF-I family transcription modulation region
    cl00055
    Location:68 → 170
    MH1; N-terminal Mad Homology 1 (MH1) domain

  7. XM_036153809.1 → XP_036009702.1  nuclear factor 1 X-type isoform X19

    Conserved Domains (2) summary
    pfam00859
    Location:166 → 370
    CTF_NFI; CTF/NF-I family transcription modulation region
    cl00055
    Location:21 → 123
    MH1; N-terminal Mad Homology 1 (MH1) domain

  8. XM_036153807.1 → XP_036009700.1  nuclear factor 1 X-type isoform X18

    Conserved Domains (2) summary
    pfam00859
    Location:166 → 371
    CTF_NFI; CTF/NF-I family transcription modulation region
    cl00055
    Location:21 → 123
    MH1; N-terminal Mad Homology 1 (MH1) domain

  9. XM_036153808.1 → XP_036009701.1  nuclear factor 1 X-type isoform X18

    Conserved Domains (2) summary
    pfam00859
    Location:166 → 371
    CTF_NFI; CTF/NF-I family transcription modulation region
    cl00055
    Location:21 → 123
    MH1; N-terminal Mad Homology 1 (MH1) domain

  10. XM_036153803.1 → XP_036009696.1  nuclear factor 1 X-type isoform X14

    UniProtKB/Swiss-Prot
    O08519, P70257, P70258, Q64192, Q99L78, Q9R1G2
    UniProtKB/TrEMBL
    D3YZ00
    Conserved Domains (3) summary
    pfam10524
    Location:6 → 42
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    pfam00859
    Location:209 → 413
    CTF_NFI; CTF/NF-I family transcription modulation region
    cl00055
    Location:64 → 166
    MH1; N-terminal Mad Homology 1 (MH1) domain

  11. XM_036153798.1 → XP_036009691.1  nuclear factor 1 X-type isoform X9

    UniProtKB/TrEMBL
    D3YZ00
    Related
    ENSMUSP00000115691.2, ENSMUST00000126806.2
    Conserved Domains (3) summary
    pfam10524
    Location:9 → 46
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    pfam00859
    Location:213 → 501
    CTF_NFI; CTF/NF-I family transcription modulation region
    cl00055
    Location:68 → 170
    MH1; N-terminal Mad Homology 1 (MH1) domain

  12. XM_030243342.2 → XP_030099202.1  nuclear factor 1 X-type isoform X1

    UniProtKB/TrEMBL
    Q5CZY4
    Conserved Domains (2) summary
    pfam00859
    Location:166 → 455
    CTF_NFI; CTF/NF-I family transcription modulation region
    cl00055
    Location:21 → 123
    MH1; N-terminal Mad Homology 1 (MH1) domain

  13. XM_006530755.5 → XP_006530818.2  nuclear factor 1 X-type isoform X1

    UniProtKB/TrEMBL
    Q5CZY4
    Conserved Domains (2) summary
    pfam00859
    Location:166 → 455
    CTF_NFI; CTF/NF-I family transcription modulation region
    cl00055
    Location:21 → 123
    MH1; N-terminal Mad Homology 1 (MH1) domain

  14. XM_011248326.4 → XP_011246628.2  nuclear factor 1 X-type isoform X8

    Conserved Domains (2) summary
    pfam00859
    Location:166 → 329
    CTF_NFI; CTF/NF-I family transcription modulation region
    cl00055
    Location:21 → 123
    MH1; N-terminal Mad Homology 1 (MH1) domain

  15. XM_006530758.5 → XP_006530821.2  nuclear factor 1 X-type isoform X4

    UniProtKB/TrEMBL
    Q5CZY4
    Conserved Domains (2) summary
    pfam00859
    Location:166 → 413
    CTF_NFI; CTF/NF-I family transcription modulation region
    cl00055
    Location:21 → 123
    MH1; N-terminal Mad Homology 1 (MH1) domain

  16. XM_006530756.5 → XP_006530819.2  nuclear factor 1 X-type isoform X2

    UniProtKB/TrEMBL
    Q5CZY4
    Conserved Domains (2) summary
    pfam00859
    Location:166 → 454
    CTF_NFI; CTF/NF-I family transcription modulation region
    cl00055
    Location:21 → 123
    MH1; N-terminal Mad Homology 1 (MH1) domain

  17. XM_006530760.5 → XP_006530823.2  nuclear factor 1 X-type isoform X7

    Conserved Domains (2) summary
    pfam00859
    Location:166 → 330
    CTF_NFI; CTF/NF-I family transcription modulation region
    cl00055
    Location:21 → 123
    MH1; N-terminal Mad Homology 1 (MH1) domain

  18. XM_006530757.5 → XP_006530820.2  nuclear factor 1 X-type isoform X3

    UniProtKB/TrEMBL
    Q5CZY4
    Conserved Domains (2) summary
    pfam00859
    Location:166 → 414
    CTF_NFI; CTF/NF-I family transcription modulation region
    cl00055
    Location:21 → 123
    MH1; N-terminal Mad Homology 1 (MH1) domain

  19. XM_030243347.2 → XP_030099207.1  nuclear factor 1 X-type isoform X1

    UniProtKB/TrEMBL
    Q5CZY4
    Conserved Domains (2) summary
    pfam00859
    Location:166 → 455
    CTF_NFI; CTF/NF-I family transcription modulation region
    cl00055
    Location:21 → 123
    MH1; N-terminal Mad Homology 1 (MH1) domain

  20. XM_030243345.2 → XP_030099205.1  nuclear factor 1 X-type isoform X1

    UniProtKB/TrEMBL
    Q5CZY4
    Conserved Domains (2) summary
    pfam00859
    Location:166 → 455
    CTF_NFI; CTF/NF-I family transcription modulation region
    cl00055
    Location:21 → 123
    MH1; N-terminal Mad Homology 1 (MH1) domain

  21. XM_036153801.1 → XP_036009694.1  nuclear factor 1 X-type isoform X2

    UniProtKB/TrEMBL
    Q5CZY4
    Conserved Domains (2) summary
    pfam00859
    Location:166 → 454
    CTF_NFI; CTF/NF-I family transcription modulation region
    cl00055
    Location:21 → 123
    MH1; N-terminal Mad Homology 1 (MH1) domain

  22. XM_030243343.2 → XP_030099203.1  nuclear factor 1 X-type isoform X1

    UniProtKB/TrEMBL
    Q5CZY4
    Conserved Domains (2) summary
    pfam00859
    Location:166 → 455
    CTF_NFI; CTF/NF-I family transcription modulation region
    cl00055
    Location:21 → 123
    MH1; N-terminal Mad Homology 1 (MH1) domain

  23. XM_036153800.1 → XP_036009693.1  nuclear factor 1 X-type isoform X12

    UniProtKB/TrEMBL
    Q5CZY4
    Conserved Domains (3) summary
    pfam10524
    Location:2 → 38
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    pfam00859
    Location:205 → 493
    CTF_NFI; CTF/NF-I family transcription modulation region
    cl00055
    Location:60 → 162
    MH1; N-terminal Mad Homology 1 (MH1) domain

  24. XM_030243341.2 → XP_030099201.1  nuclear factor 1 X-type isoform X11

    UniProtKB/TrEMBL
    Q5CZY4
    Conserved Domains (3) summary
    pfam00859
    Location:209 → 497
    CTF_NFI; CTF/NF-I family transcription modulation region
    pfam10524
    Location:6 → 42
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    cl00055
    Location:64 → 166
    MH1; N-terminal Mad Homology 1 (MH1) domain

  25. XM_036153806.1 → XP_036009699.1  nuclear factor 1 X-type isoform X17

    Conserved Domains (3) summary
    pfam10524
    Location:9 → 49
    NfI_DNAbd_pre-N; Nuclear factor I protein pre-N-terminus
    pfam00859
    Location:216 → 380
    CTF_NFI; CTF/NF-I family transcription modulation region
    cl00055
    Location:71 → 173
    MH1; N-terminal Mad Homology 1 (MH1) domain
Nucleotide Protein Strain
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
P70257.2 GenPept UniProtKB/Swiss-Prot:P70257

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