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mdt-17 Mediator of RNA polymerase II transcription subunit 17 [ Caenorhabditis elegans ]

Gene ID: 180325, updated on 2-Nov-2024

Summary

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Official Symbol
mdt-17
Official Full Name
Mediator of RNA polymerase II transcription subunit 17
Primary source
WormBase:WBGene00007017
Locus tag
CELE_Y113G7B.18
See related
AllianceGenome:WB:WBGene00007017
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable transcription coregulator activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. Predicted to be part of core mediator complex and mediator complex. Human ortholog(s) of this gene implicated in infantile cerebral and cerebellar atrophy with postnatal progressive microcephaly. Orthologous to human MED17 (mediator complex subunit 17). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See mdt-17 in Genome Data Viewer
Location:
chromosome: V
Exon count:
8
Sequence:
Chromosome: V; NC_003283.11 (20250806..20267247, complement)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene DNA replication complex GINS protein SLD5;DNA replication complex GINS protein SLD5 C-terminal domain-containing protein Neighboring gene SANT domain-containing protein;SWI/SNF complex subunit SMARCC2;SWIRM-assoc_1 domain-containing protein Neighboring gene Protein arginine N-methyltransferase 1 Neighboring gene CDK5RAP3 protein homolog

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Proteomic Interactome of C. elegans Mediator Complex Subunit 28 (MDT-28) Reveals Predominant Association with a Restricted Set of Core Mediator Subunits and an Affinity to Additional Structural and Enzymatic Proteins. Yilma P, et al. Folia Biol (Praha), 2019. PMID 32362303
  2. A unified nomenclature for protein subunits of mediator complexes linking transcriptional regulators to RNA polymerase II. Bourbon HM, et al. Mol Cell, 2004 Jun 4. PMID 15175151
  3. CEST-2.2 overexpression alters lipid metabolism and extends longevity of mitochondrial mutants. Piazzesi A, et al. EMBO Rep, 2022 May 4. PMID 35297148, Free PMC Article
  4. Transcription mechanisms. Blackwell TK, et al. WormBook, 2006 Sep 5. PMID 18050436, Free PMC Article
  5. A transcriptional cofactor regulatory network for the C. elegans intestine. Horowitz BB, et al. G3 (Bethesda), 2023 Jul 5. PMID 37119809, Free PMC Article

See all (12) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables transcription coregulator activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables transcription coregulator activity IEA
Inferred from Electronic Annotation
more info
  
Process Evidence Code Pubs
involved_in regulation of transcription by RNA polymerase II IBA
Inferred from Biological aspect of Ancestor
more info
  
involved_in regulation of transcription by RNA polymerase II IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
part_of core mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IBA
Inferred from Biological aspect of Ancestor
more info
  
part_of mediator complex IEA
Inferred from Electronic Annotation
more info
  
located_in nucleus IEA
Inferred from Electronic Annotation
more info
  

General protein information

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Preferred Names
Mediator of RNA polymerase II transcription subunit 17
NP_001256910.1
  • Confirmed by transcript evidence
NP_001379536.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    20250806..20267247 complement
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001269981.5 → NP_001256910.1  Mediator of RNA polymerase II transcription subunit 17 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256910.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    G2HJZ8, G2HJZ9, Q9NAL4

  2. NM_001392708.1 → NP_001379536.1  Mediator of RNA polymerase II transcription subunit 17 [Caenorhabditis elegans]

    Status: REVIEWED

Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9NAL4.4

Gene LinkOut

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