U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

mlt-11 Papilin [ Caenorhabditis elegans ]

Gene ID: 180352, updated on 2-Nov-2024

Summary

Go to the top of the page Help
Official Symbol
mlt-11
Official Full Name
Papilin
Primary source
WormBase:WBGene00012186
Locus tag
CELE_W01F3.3
See related
AllianceGenome:WB:WBGene00012186
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be active in extracellular space. Is expressed in hypodermis. [provided by Alliance of Genome Resources, Nov 2024]
NEW
Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help
See mlt-11 in Genome Data Viewer
Location:
chromosome: V
Exon count:
16
Sequence:
Chromosome: V; NC_003283.11 (20667205..20678537)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Menorin Neighboring gene Uncharacterized protein Neighboring gene ncRNA Neighboring gene ncRNA Neighboring gene G-protein coupled receptors family 1 profile domain-containing protein Neighboring gene ncRNA

Genomic regions, transcripts, and products

Go to the top of the page Help
Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the pageHelp

Related articles in PubMed

  1. The C. elegans mapping locus rol-9 is encoded by a gain-of-function mutation in mlt-11. Rich MS, et al. MicroPubl Biol, 2022. PMID 35005481, Free PMC Article
  2. Experimental considerations for study of C. elegans lysosomal proteins. Clancy JC, et al. G3 (Bethesda), 2023 Apr 11. PMID 36748711, Free PMC Article
  3. The Caenorhabditis elegans heterochronic regulator LIN-14 is a novel transcription factor that controls the developmental timing of transcription from the insulin/insulin-like growth factor gene ins-33 by direct DNA binding. Hristova M, et al. Mol Cell Biol, 2005 Dec. PMID 16314527, Free PMC Article
  4. Mechanistic impacts of bacterial diet on dopaminergic neurodegeneration in a Caenorhabditis elegans α-synuclein model of Parkinson's disease. Gaeta AL, et al. iScience, 2023 Jun 16. PMID 37260751, Free PMC Article
  5. NHR-23 activity is necessary for C. elegans developmental progression and apical extracellular matrix structure and function. Johnson LC, et al. Development, 2023 May 15. PMID 37129010, Free PMC Article

See all (15) citations in PubMed

GeneRIFs: Gene References Into Functions

Interactions

Go to the top of the page Help
Products Interactant Other Gene Complex Source Pubs Description

General gene information

Go to the top of the page Help

Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables serine-type endopeptidase inhibitor activity IBA
Inferred from Biological aspect of Ancestor
more info
  
enables serine-type endopeptidase inhibitor activity IEA
Inferred from Electronic Annotation
more info
  
Component Evidence Code Pubs
is_active_in extracellular space IBA
Inferred from Biological aspect of Ancestor
more info
  

General protein information

Go to the top of the page Help
Preferred Names
Papilin
NP_001256938.1
  • Confirmed by transcript evidence
NP_001256939.1
  • Confirmed by transcript evidence
NP_001256940.1
  • Confirmed by transcript evidence
NP_001256941.1
  • Confirmed by transcript evidence
NP_001256942.1
  • Confirmed by transcript evidence
NP_001256943.1
  • Confirmed by transcript evidence
NP_001256944.1
  • Confirmed by transcript evidence
NP_001256945.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    20667205..20678537
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001270015.4 → NP_001256944.1  Papilin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256944.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H9G335
    Conserved Domains (5) summary
    cd00109
    Location:514 → 566
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    cd00191
    Location:140 → 188
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    pfam00014
    Location:1429 → 1481
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam14625
    Location:2163 → 2209
    Lustrin_cystein; Lustrin, cysteine-rich repeated domain
    cl00101
    Location:582 → 634
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

  2. NM_001270013.3 → NP_001256942.1  Papilin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256942.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C1P658
    Conserved Domains (6) summary
    COG5665
    Location:1802 → 2040
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    cd00191
    Location:232 → 280
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    pfam00014
    Location:2047 → 2099
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam14625
    Location:2781 → 2827
    Lustrin_cystein; Lustrin, cysteine-rich repeated domain
    cd00109
    Location:608 → 658
    Kunitz-type; Kunitz/Bovine pancreatic trypsin inhibitor (BPTI) domain
    cd22626
    Location:2112 → 2162
    Kunitz_ixolaris_2; Kunitz-type domain 2 (K2) of Ixolaris, and similar proteins

  3. NM_001270011.3 → NP_001256940.1  Papilin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256940.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    O45881
    Conserved Domains (5) summary
    cd00109
    Location:735 → 787
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    cd00191
    Location:361 → 409
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    pfam00014
    Location:1222 → 1274
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam14625
    Location:1956 → 2002
    Lustrin_cystein; Lustrin, cysteine-rich repeated domain
    cl00101
    Location:803 → 855
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

  4. NM_001270012.3 → NP_001256941.1  Papilin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256941.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C1P659
    Conserved Domains (6) summary
    COG5665
    Location:1922 → 2160
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    cd00191
    Location:361 → 409
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    pfam00014
    Location:2167 → 2219
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam14625
    Location:2901 → 2947
    Lustrin_cystein; Lustrin, cysteine-rich repeated domain
    cd00109
    Location:728 → 778
    Kunitz-type; Kunitz/Bovine pancreatic trypsin inhibitor (BPTI) domain
    cd22626
    Location:2232 → 2282
    Kunitz_ixolaris_2; Kunitz-type domain 2 (K2) of Ixolaris, and similar proteins

  5. NM_001270009.3 → NP_001256938.1  Papilin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256938.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B9WRT9
    Conserved Domains (5) summary
    cd00109
    Location:735 → 787
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    cd00191
    Location:361 → 409
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    pfam00014
    Location:2176 → 2228
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam14625
    Location:2910 → 2956
    Lustrin_cystein; Lustrin, cysteine-rich repeated domain
    cl00101
    Location:803 → 855
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

  6. NM_001270010.3 → NP_001256939.1  Papilin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256939.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    C1P660
    Conserved Domains (6) summary
    COG5665
    Location:1405 → 1643
    COG5665; CCR4-NOT transcriptional regulation complex, NOT5 subunit [Transcription]
    cd00191
    Location:361 → 409
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    pfam00014
    Location:1650 → 1702
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam14625
    Location:2384 → 2430
    Lustrin_cystein; Lustrin, cysteine-rich repeated domain
    cd00109
    Location:737 → 787
    Kunitz-type; Kunitz/Bovine pancreatic trypsin inhibitor (BPTI) domain
    cd22626
    Location:1715 → 1765
    Kunitz_ixolaris_2; Kunitz-type domain 2 (K2) of Ixolaris, and similar proteins

  7. NM_001270014.3 → NP_001256943.1  Papilin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256943.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H9G336
    Conserved Domains (5) summary
    cd00109
    Location:514 → 566
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    cd00191
    Location:140 → 188
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    pfam00014
    Location:1574 → 1626
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam14625
    Location:2308 → 2354
    Lustrin_cystein; Lustrin, cysteine-rich repeated domain
    cl00101
    Location:582 → 634
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.

  8. NM_001270016.3 → NP_001256945.1  Papilin [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256945.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    H9G334
    Conserved Domains (5) summary
    cd00109
    Location:505 → 557
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
    cd00191
    Location:140 → 188
    TY; Thyroglobulin type I repeats.; The N-terminal region of human thyroglobulin contains 11 type-1 repeats TY repeats are proposed to be inhibitors of cysteine proteases
    pfam00014
    Location:1420 → 1472
    Kunitz_BPTI; Kunitz/Bovine pancreatic trypsin inhibitor domain
    pfam14625
    Location:2154 → 2200
    Lustrin_cystein; Lustrin, cysteine-rich repeated domain
    cl00101
    Location:573 → 625
    KU; BPTI/Kunitz family of serine protease inhibitors; Structure is a disulfide rich alpha+beta fold. BPTI (bovine pancreatic trypsin inhibitor) is an extensively studied model structure.
Nucleotide Protein
Heading Accession and Version

Gene LinkOut

The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

Molecular Biology Databases
Research Materials
Tools