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num-1 Numb-related protein 1;PID domain-containing protein [ Caenorhabditis elegans ]

Gene ID: 180367, updated on 2-Nov-2024

Summary

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Official Symbol
num-1
Official Full Name
Numb-related protein 1;PID domain-containing protein
Primary source
WormBase:WBGene00003830
Locus tag
CELE_T03D8.1
See related
AllianceGenome:WB:WBGene00003830
Gene type
protein coding
RefSeq status
REVIEWED
Organism
Caenorhabditis elegans (strain: Bristol N2)
Lineage
Eukaryota; Metazoa; Ecdysozoa; Nematoda; Chromadorea; Rhabditida; Rhabditina; Rhabditomorpha; Rhabditoidea; Rhabditidae; Peloderinae; Caenorhabditis
Summary
Enables enzyme binding activity and protein domain specific binding activity. Involved in endocytic recycling; phospholipid transport; and protein targeting to membrane. Located in basolateral plasma membrane and cytoplasm. Is expressed in several structures, including alimentary muscle; hermaphrodite gonad; nerve ring; pseudocoelom; and rectal valve cell. Orthologous to human NUMB (NUMB endocytic adaptor protein) and NUMBL (NUMB like endocytic adaptor protein). [provided by Alliance of Genome Resources, Nov 2024]
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Genomic context

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See num-1 in Genome Data Viewer
Location:
chromosome: V
Exon count:
10
Sequence:
Chromosome: V; NC_003283.11 (20829811..20837619)

Chromosome V - NC_003283.11Genomic Context describing neighboring genes Neighboring gene Gamma-glutamyltransferase;Gamma-glutamyltranspeptidase 1 Neighboring gene Receptor-type guanylate cyclase gcy-22 Neighboring gene Ground-like domain-containing protein Neighboring gene Neuroendocrine protein 7B2 Neighboring gene Small ribosomal subunit protein uS12m Neighboring gene Ribosomal RNA-processing protein 42 Neighboring gene Sugar phosphate phosphatase

Genomic regions, transcripts, and products

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Genomic Sequence:
NC_003283.11

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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Related articles in PubMed

  1. Caenorhabditis elegans num-1 negatively regulates endocytic recycling. Nilsson L, et al. Genetics, 2008 May. PMID 18493060, Free PMC Article
  2. Structural properties and mechanisms that govern association of C kinase adapter 1 with protein kinase C3 and the cell periphery. Zhang L, et al. J Biol Chem, 2001 Mar 30. PMID 11134025
  3. A novel adapter protein employs a phosphotyrosine binding domain and exceptionally basic N-terminal domains to capture and localize an atypical protein kinase C: characterization of Caenorhabditis elegans C kinase adapter 1, a protein that avidly binds protein kinase C3. Zhang L, et al. J Biol Chem, 2001 Mar 30. PMID 11134024
  4. Caenorhabditis elegans numb inhibits endocytic recycling by binding TAT-1 aminophospholipid translocase. Nilsson L, et al. Traffic, 2011 Dec. PMID 21917090
  5. Caenorhabditis elegans SAND-1 is essential for RAB-7 function in endosomal traffic. Poteryaev D, et al. EMBO J, 2007 Jan 24. PMID 17203072, Free PMC Article

See all (16) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?
  1. TAT-1 is differentially spliced during development and that TAT-1C-specific splicing occurs in the intestine where NUM-1A is known to function.
    Title: Caenorhabditis elegans numb inhibits endocytic recycling by binding TAT-1 aminophospholipid translocase.
Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products Interactant Other Gene Complex Source Pubs Description

General gene information

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Markers

Homology

Gene Ontology Provided by WormBase

Function Evidence Code Pubs
enables ATPase binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein domain specific binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables protein kinase C binding IPI
Inferred from Physical Interaction
more info
 PubMed 
enables transmembrane receptor protein tyrosine kinase adaptor activity IPI
Inferred from Physical Interaction
more info
 PubMed 
Process Evidence Code Pubs
involved_in cell surface receptor protein tyrosine kinase signaling pathway IEA
Inferred from Electronic Annotation
more info
  
involved_in endocytic recycling IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in phospholipid transport IMP
Inferred from Mutant Phenotype
more info
 PubMed 
involved_in protein targeting to membrane IDA
Inferred from Direct Assay
more info
 PubMed 
Component Evidence Code Pubs
located_in basolateral plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cell cortex IEA
Inferred from Electronic Annotation
more info
  
located_in cytoplasm IDA
Inferred from Direct Assay
more info
 PubMed 
located_in cytoplasm IEA
Inferred from Electronic Annotation
more info
  
located_in cytoskeleton IEA
Inferred from Electronic Annotation
more info
  
located_in membrane IEA
Inferred from Electronic Annotation
more info
  
located_in plasma membrane IDA
Inferred from Direct Assay
more info
 PubMed 

General protein information

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Preferred Names
Numb-related protein 1;PID domain-containing protein
NP_001024097.1
  • Partially confirmed by transcript evidence
NP_001024098.1
  • Confirmed by transcript evidence
NP_001129904.1
  • Confirmed by transcript evidence
NP_001256958.1
  • Confirmed by transcript evidence
NP_508021.1
  • Confirmed by transcript evidence

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

  1. NC_003283.11 Reference assembly

    Range
    20829811..20837619
    Download
    GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

  1. NM_001136432.6 → NP_001129904.1  PID domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001129904.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    B5BM46
    Conserved Domains (2) summary
    cd01268
    Location:181 → 316
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:410 → 445
    NumbF; NUMB domain

  2. NM_075620.6 → NP_508021.1  Numb-related protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_508021.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9BKB5, Q9XTY4, Q9XTY6
    Conserved Domains (2) summary
    cd01268
    Location:92 → 227
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:321 → 379
    NumbF; NUMB domain

  3. NM_001028927.3 → NP_001024098.1  Numb-related protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024098.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XTY6
    Conserved Domains (2) summary
    cd01268
    Location:48 → 183
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:277 → 339
    NumbF; NUMB domain

  4. NM_001028926.5 → NP_001024097.1  Numb-related protein 1 [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001024097.1

    Status: REVIEWED

    UniProtKB/Swiss-Prot
    Q9XTY6

  5. NM_001270029.3 → NP_001256958.1  PID domain-containing protein [Caenorhabditis elegans]

    See identical proteins and their annotated locations for NP_001256958.1

    Status: REVIEWED

    UniProtKB/TrEMBL
    F1LIN5
    Conserved Domains (2) summary
    cd01268
    Location:34 → 169
    PTB_Numb; Numb Phosphotyrosine-binding (PTB) domain
    pfam06311
    Location:263 → 298
    NumbF; NUMB domain
Nucleotide Protein
Heading Accession and Version
Protein Accession Links
GenPept Link UniProtKB Link
Q9XTY6.1

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